| Clinical use of digitalis materials. | |
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MedLine Citation:
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PMID: 3905879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Digitalis is a drug widely used in modern medicine for the control of ventricular response in atrial fibrillation and the treatment of congestive heart failure (CHF). Recently, the use of digitalis for the treatment of CHF in patients in sinus rhythm has become quite controversial. The findings of several clinical studies suggest a small but definite hemodynamic or clinical improvement in patients treated with digitalis. These effects are limited by the onset of toxicity, which is at least partially mediated via the central nervous system. If the inotropic effect of the drug could be separated from the central nervous system effect, much higher doses of digitalis could be tolerated and presumably a greater therapeutic effect could be obtained. |
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Authors:
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B Levitt; D L Keefe |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 25 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1986-01-08 Completed Date: 1986-01-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 507-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Digitalis Glycosides / adverse effects, therapeutic use* Electrocardiography Electrophysiology Heart Failure / drug therapy* Humans Nervous System Diseases / chemically induced Pulmonary Wedge Pressure / drug effects Sympathetic Nervous System / drug effects Time Factors Vagus Nerve / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Digitalis Glycosides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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