Document Detail


Clinical use of beta-blockers in patients with heart failure.
MedLine Citation:
PMID:  10908097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recognition of the role of the sympathetic nervous system in chronic heart failure has resulted in dramatic changes in the way heart failure is viewed, providing strong evidence for the therapeutic role for beta-adrenergic blocking agents. This treatment strategy does not provide short-term hemodynamic improvement and may even worsen symptoms initially. However, beta-blockers can be administered with good or even excellent tolerability by slowly withdrawing adrenergic support to the failing heart. Results of clinical trials have shown that long-term treatment with beta-blockers improves ventricular function and reduces mortality rates in patients with mild-to-moderate heart failure. Although the improvement in ventricular function is a beta-blocker class effect, there are distinct differences in antiadrenergic activity and tolerability among the first-, second-, and third-generation agents. These differences--as well as practical strategies for dose titration and the management of decompensation--are the focus of this article.
Authors:
E J Eichhorn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  6     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2000-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-6     Citation Subset:  IM    
Affiliation:
Department of Veterans Affairs Hospital, University of Texas, Southwestern Medical Center, Dallas 75216, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Cardiovascular Diseases / drug therapy
Dose-Response Relationship, Drug
Heart Failure / drug therapy*
Hemodynamics / drug effects*
Humans
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Severity of Illness Index
Time Factors
Vasodilator Agents / therapeutic use*
Ventricular Dysfunction, Left / drug therapy
Ventricular Remodeling / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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