Document Detail


Clinical update on the use of niacin for the treatment of dyslipidemia.
MedLine Citation:
PMID:  15645997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To provide nurse practitioners (NPs) with clinical and practical information about the use of niacin in the treatment of dyslipidemia. DATA SOURCES: Research-based and review articles in the medical literature and National Cholesterol Education Program guidelines. CONCLUSIONS: Niacin provides beneficial effects on all major lipid fractions, particularly high-density lipoprotein cholesterol and triglycerides. Niacin also reduces low-density lipoprotein (LDL) cholesterol; lipoprotein (a); and the number of highly atherogenic small, dense LDL particles. Niacin promotes angiographic regression when used in combination with other drugs that lower LDL cholesterol and can reduce cardiovascular risk in patients with coronary heart disease. Several niacin formulations are available, but the safety (i.e., from hepatotoxicity) and tolerability (i.e., severity of flushing) of these niacin formulations may differ. IMPLICATIONS FOR PRACTICE: Niacin therapy is appropriate for many types of lipid abnormalities, including complex dyslipidemias. NPs can take several steps to minimize potential side effects of niacin therapy and to ensure that patients adhere to this important intervention.
Authors:
Kathy Berra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of the American Academy of Nurse Practitioners     Volume:  16     ISSN:  1041-2972     ISO Abbreviation:  J Am Acad Nurse Pract     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-13     Completed Date:  2005-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8916634     Medline TA:  J Am Acad Nurse Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  526-34     Citation Subset:  N    
Affiliation:
Stanford Prevention Research Center, California, USA. kberra@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Antilipemic Agents / adverse effects,  therapeutic use*
Humans
Hyperlipidemias / drug therapy*,  epidemiology
Niacin / adverse effects,  therapeutic use*
Practice Guidelines as Topic
Safety
Treatment Outcome
United States / epidemiology
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 59-67-6/Niacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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