| Clinical tumour markers in lung cancer. | |
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MedLine Citation:
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PMID: 7539317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Within the past few years, the measurement of serum and tissue markers has had an increasing influence on clinical decisions about initial treatment and follow-up. Lung cancer illustrates the types and importance of these various markers. This review presents data concerning the most studied and interesting markers in non-small cell (NSCLC) and small cell lung cancer (SCLC). CEA, TPA, SCC-Ag, CYFRA 21-1, ferritin, CA19-9, CA50, CA242, H-K-N-ras mutations and p53 mutation seem to be the most prolific in NSCLC, while NSE, BN/GRP, CK-BB, NCAM, IL-2R, IGF-I, transferrin, ANP, mAb (cluster 5), Le-y and c-N-L-myc mutation are markers in SCLC patients. Some of these serum markers might be useful adjuncts for monitoring response to therapy, including early detection of tumour reactivation to allow curative therapy and rapid detection of treatment failure to allow change of the regimen. The study of these markers also may lead to a better understanding of the biological characteristics of lung cancer. The information derived from these biological studies represents the most promising avenue towards new treatment strategies, as well as attempts at secondary prevention. |
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Authors:
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J Niklinski; M Furman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) Volume: 4 ISSN: 0959-8278 ISO Abbreviation: Eur. J. Cancer Prev. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-06-30 Completed Date: 1995-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9300837 Medline TA: Eur J Cancer Prev Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 129-38 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, Medical School, Bialystok, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Neoplasm
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blood Carcinoembryonic Antigen / blood Carcinoma, Non-Small-Cell Lung / blood*, genetics Carcinoma, Small Cell / blood* Genes, p53 Genes, ras Humans Keratins / blood Lung Neoplasms / blood*, genetics Peptides / blood Phosphopyruvate Hydratase / blood Tissue Polypeptide Antigen Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Peptides; 0/Tissue Polypeptide Antigen; 0/Tumor Markers, Biological; 0/tumor antigen TA-4, human; 68238-35-7/Keratins; EC 4.2.1.11/Phosphopyruvate Hydratase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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