| Clinical trials with new oral anticoagulants. Additive value of indirect comparisons also named network meta-analyses. | |
| | |
MedLine Citation:
|
PMID: 23344716 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To compare the efficacy and safety of the new oral anticoagulants (NOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is a need for an unbiased comparative assessment of the benefits and risks of the NOACs, based on the available trial data. Indirect or mixed treatment comparisons may be an useful tool to overcome these limitations also known as network meta-analysis (NMA).The aim of this paper is to give an overview on published NMAs for dabigatran, rivaroxaban and apixaban, each assessed against warfarin in patients with atrial fibrillation, and against enoxaparin in patients undergoing total knee and total hip replacement surgery, in order to obtain insights into the comparability of the adopted methodological techniques. |
| | |
Authors:
|
J Harenberg; C Weiss |
Related Documents
:
|
23343446 - History and therapeutic rationale of long acting antipsychotics. 23556416 - Current pharmacotherapy of nocturia. 23203776 - Familial and sporadic hemiplegic migraine: diagnosis and treatment. 20354236 - Differences in perceptions of the diagnosis and treatment of obstructive sleep apnea an... 19201166 - Perceived negative attitude of others as an early sign of psychosis. 3167406 - Reshaping the psyche. the concurrent improvement in appearance and mental state after r... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
|
Title: Hamostaseologie Volume: 33 ISSN: 0720-9355 ISO Abbreviation: Hamostaseologie Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8204531 Medline TA: Hamostaseologie Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Job Harenberg, MD, Professor of Medicine, Department of Clinical Pharmacology, Medical Faculty Mannheim, University of Heidelberg, Maybachstr. 14, 68169 Mannheim, Germany, Tel. +49/(0)621/383 96 23, Fax +49/(0)621/383 96 22, E-mail: job.harenberg@medma.uni-heidelberg.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An Alternative Look at Code Evolution: Using Non-canonical Codes to Evaluate Adaptive and Historic M...
Next Document: Implicit chaining in cotton-top tamarins (Saguinus oedipus) with elements equated for probability of...