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Clinical trials with new oral anticoagulants. Additive value of indirect comparisons also named network meta-analyses.
MedLine Citation:
PMID:  23344716     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To compare the efficacy and safety of the new oral anticoagulants (NOAC), ideally head-to-head clinical trials should be performed. Given the expense of such an undertaking, it is highly unlikely that such a comparison would be performed. Therefore, there is a need for an unbiased comparative assessment of the benefits and risks of the NOACs, based on the available trial data. Indirect or mixed treatment comparisons may be an useful tool to overcome these limitations also known as network meta-analysis (NMA).The aim of this paper is to give an overview on published NMAs for dabigatran, rivaroxaban and apixaban, each assessed against warfarin in patients with atrial fibrillation, and against enoxaparin in patients undergoing total knee and total hip replacement surgery, in order to obtain insights into the comparability of the adopted methodological techniques.
Authors:
J Harenberg; C Weiss
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Hamostaseologie     Volume:  33     ISSN:  0720-9355     ISO Abbreviation:  Hamostaseologie     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8204531     Medline TA:  Hamostaseologie     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Job Harenberg, MD, Professor of Medicine, Department of Clinical Pharmacology, Medical Faculty Mannheim, University of Heidelberg, Maybachstr. 14, 68169 Mannheim, Germany, Tel. +49/(0)621/383 96 23, Fax +49/(0)621/383 96 22, E-mail: job.harenberg@medma.uni-heidelberg.de.
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