| Clinical trials with halofantrine hydrochloride in Malawi. | |
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MedLine Citation:
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PMID: 2899238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two clinical trials of the phenanthrene methanol compound halofantrine in the treatment of Plasmodium falciparum were conducted in Malawi, in areas where the parasite was known to be chloroquine resistant. In the first trial all 46 patients had symptoms of malaria and parasite densities ranging from 2500/microliter to 212,000/microliter. They were given a single dose of halofantrine hydrochloride, 16 mg/kg body weight. The recrudescence rate on day 14 of follow up was unacceptably high (38%). In the second trial the dose given was 8 mg/kg 6 hourly for three doses. Of the 49 children followed up for 14 days, 47 became aparasitaemic--ie, the cure rate was 96%. In both trials the drug was very well tolerated. Halofantrine hydrochloride seems to be effective against P falciparum chloroquine sensitive and resistant strains in Africa. |
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Authors:
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J Wirima; C Khoromana; M E Molyneux; H M Gilles |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Lancet Volume: 2 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-08-25 Completed Date: 1988-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 250-2 Citation Subset: AIM; IM |
Affiliation:
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Kamuzu Central Hospital, Lilongwe, Malawi. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Animals Antimalarials / administration & dosage*, pharmacology, therapeutic use Child Child, Preschool Chloroquine / therapeutic use Clinical Trials as Topic Drug Administration Schedule Drug Evaluation Female Follow-Up Studies Humans Infant Malaria / blood, drug therapy*, epidemiology Malawi Male Phenanthrenes / administration & dosage*, pharmacology, therapeutic use Plasmodium falciparum Recurrence Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Phenanthrenes; 36167-63-2/halofantrine; 54-05-7/Chloroquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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