Document Detail


Clinical trials with RU 486 (mifepristone): an update.
MedLine Citation:
PMID:  2694739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reviews much of the clinical data obtained with the antiprogestin RU 486 (mifepristone) in the fields of obstetrics and gynecology. To interrupt early pregnancy (less than 50 days of amenorrhea) RU 486 as a single dose of 600 mg followed 36-48 hours later by a prostaglandin derivative, constitutes an alternative to vacuum aspiration or dilatation and curettage (D and C). All three methods have comparable efficacy, provided that they are performed in centers with adequate medical facilities. RU 486 is the first antiprogestational steroid available for clinical purposes. Its pharmacological properties have been reviewed in detail elsewhere (1,2). The present paper reviews the main clinical data obtained during trials monitored by Roussel Uclaf.
Authors:
A Ulmann; C Dubois
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica. Supplement     Volume:  149     ISSN:  0300-8835     ISO Abbreviation:  Acta Obstet Gynecol Scand Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-07     Completed Date:  1990-03-07     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0337655     Medline TA:  Acta Obstet Gynecol Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  9-11     Citation Subset:  IM    
Affiliation:
Roussel Uclaf Laboratories, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
16,16-Dimethylprostaglandin E2 / administration & dosage,  analogs & derivatives
Abortifacient Agents, Nonsteroidal / administration & dosage
Abortion, Induced*
Alprostadil / administration & dosage,  analogs & derivatives
Clinical Trials as Topic
Dinoprostone / administration & dosage,  analogs & derivatives
Female
Humans
Labor, Induced
Mifepristone* / administration & dosage,  adverse effects
Pregnancy
Pregnancy Trimester, Second
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 363-24-6/Dinoprostone; 39746-25-3/16,16-Dimethylprostaglandin E2; 60325-46-4/sulprostone; 61263-35-2/meteneprost; 64318-79-2/gemeprost; 745-65-3/Alprostadil; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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