| Clinical trials with RU 486 (mifepristone): an update. | |
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MedLine Citation:
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PMID: 2694739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews much of the clinical data obtained with the antiprogestin RU 486 (mifepristone) in the fields of obstetrics and gynecology. To interrupt early pregnancy (less than 50 days of amenorrhea) RU 486 as a single dose of 600 mg followed 36-48 hours later by a prostaglandin derivative, constitutes an alternative to vacuum aspiration or dilatation and curettage (D and C). All three methods have comparable efficacy, provided that they are performed in centers with adequate medical facilities. RU 486 is the first antiprogestational steroid available for clinical purposes. Its pharmacological properties have been reviewed in detail elsewhere (1,2). The present paper reviews the main clinical data obtained during trials monitored by Roussel Uclaf. |
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Authors:
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A Ulmann; C Dubois |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica. Supplement Volume: 149 ISSN: 0300-8835 ISO Abbreviation: Acta Obstet Gynecol Scand Suppl Publication Date: 1989 |
Date Detail:
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Created Date: 1990-03-07 Completed Date: 1990-03-07 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0337655 Medline TA: Acta Obstet Gynecol Scand Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 9-11 Citation Subset: IM |
Affiliation:
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Roussel Uclaf Laboratories, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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16,16-Dimethylprostaglandin E2
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administration & dosage,
analogs & derivatives Abortifacient Agents, Nonsteroidal / administration & dosage Abortion, Induced* Alprostadil / administration & dosage, analogs & derivatives Clinical Trials as Topic Dinoprostone / administration & dosage, analogs & derivatives Female Humans Labor, Induced Mifepristone* / administration & dosage, adverse effects Pregnancy Pregnancy Trimester, Second |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 363-24-6/Dinoprostone; 39746-25-3/16,16-Dimethylprostaglandin E2; 60325-46-4/sulprostone; 61263-35-2/meteneprost; 64318-79-2/gemeprost; 745-65-3/Alprostadil; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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