| Clinical trials in youth with type 2 diabetes. | |
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MedLine Citation:
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PMID: 20456085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 2 diabetes in youth was almost unheard of only two decades ago. However, tracking the recent dramatic rise in childhood obesity, type 2 diabetes has become increasingly prevalent. Thus, there is an urgent need for high-quality clinical trials to increase in-depth knowledge about pathophysiology, optimal treatment, and prevention. We therefore systematically reviewed published and ongoing clinical trials of type 2 diabetes in children and adolescents. The results demonstrate that (i) few randomized clinical trials have been completed and published in children with type 2 diabetes; (ii) ongoing trials in type 1 diabetes clearly outnumber trials in type 2 diabetes; and (iii) recruitment and enrollment into the latter trials are challenging, however once achieved, drop-out rates are not excessively high. We conclude that type 2 diabetes in youth is an important but difficult new field of clinical research, and we discuss the existing barriers to successful recruitment, conduct, and support of these clinical trials. |
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Authors:
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Julie Anne L Gemmill; Rebecca J Brown; Radha Nandagopal; Luisa M Rodriguez; Kristina I Rother |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric diabetes Volume: 12 ISSN: 1399-5448 ISO Abbreviation: Pediatr Diabetes Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-26 Completed Date: 2011-04-29 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: Denmark |
Other Details:
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Languages: eng Pagination: 50-7 Citation Subset: IM |
Copyright Information:
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Published 2010. This article is a US Government work and is in the public domain in the USA. |
Affiliation:
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Clinical Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Clinical Trials as Topic* Diabetes Mellitus, Type 2 / drug therapy* Humans Patient Selection Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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Z01 DK047049-01/DK/NIDDK NIH HHS; Z01 DK047049-02/DK/NIDDK NIH HHS; Z99 DK999999/DK/NIDDK NIH HHS; ZIA DK047049-03/DK/NIDDK NIH HHS; ZIA DK047049-04/DK/NIDDK NIH HHS; ZIA DK075052-01/DK/NIDDK NIH HHS |
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