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Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury.
MedLine Citation:
PMID:  18616646     Owner:  NLM     Status:  Publisher    
Background: A partially hydrolysed and dried product of pacific whiting fish is marketed as a health food supplement supporting 'intestinal health'. We examined whether it influenced the small intestinal damaging side effects of the non-steroidal anti-inflammatory drug, indomethacin. Methods: Eight human volunteers completed a double-blind, placebo-controlled, crossover protocol of clinically relevant dose of indomethacin (50 mg tds po for 5 days) with 7 days of fish hydrolysate or placebo starting 2 days prior to indomethacin. Changes in gut permeability were assessed using 5 h urinary lactulose: rhamnose (L/R) ratios. Results: Fish hydrolysate given alone did not affect permeability. In the main study (N=8), baseline values were similar for both arms (0.28 +/- 0.05 and 0.35 +/- 0.07). Administration of indomethacin (+ placebo) caused a five-fold rise in L/R ratios (increasing to 1.54 +/- 0.35) whereas L/R ratios in the same subjects ingesting indomethacin + fish hydrolysate, was only 0.59 +/- 0.14, (p <0.01 vs. indomethacin alone). Dyspeptic symptoms occurred in 4/8 subjects taking indomethacin alone but 0/8 when hydrolysate was co-administered. Conclusion: Natural bioactive products (nutriceuticals), such as this, may provide a novel approach to the prevention and treatment of NSAID-induced and other gastrointestinal injurious conditions.
T Marchbank; J K Limdi; A Mahmood; G Elia; R J Playford
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-6-26
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  -     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts & The London School of Medicine, Queen Mary University of London, London, UK.
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