| Clinical trial: low plasma cholesterol and oxidative stress predict rapid virological response to standard therapy with peginterferon and ribavirin in HCV patients. | |
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MedLine Citation:
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PMID: 19493257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Rapid virological response (RVR) is the best predictor of sustained response to standard HCV treatment. AIM: To evaluate predictive factors of RVR. METHODS: Sixty-five patients (mean age 52.6 +/- 13.8; 37 genotype-1, and 28 genotypes-2/3) were consecutively treated with pegIFN-alpha 2a or 2b once weekly plus daily ribavirin based on body weight for 24 or 48 weeks, according to genotype. RVR was defined as undetectable HCV-RNA at week 4. RESULTS: Twenty-seven percent of patients achieved RVR in genotypes 1 and 60.7% in genotypes 2/3 (P < 0.01). Rapid responders had higher mean serum baseline total and LDL-cholesterol levels (P < 0.01). RVR was 20.0% in the bottom tertile of total cholesterol and 63.6% in the top tertile (P < 0.01). HCV-RNA levels at week 4 were positively correlated with baseline serum insulin (P < 0.01), HOMA-IR (P < 0.01), body mass index (P < 0.05) and number of components of metabolic syndrome (P < 0.01) and negatively correlated with cholesterol levels (P < 0.05). At multivariate analysis, age, LDL-cholesterol, HCV genotype and serum 8-iso-PGF 2 alpha, a marker of oxidative stress, were independent predictors of RVR. CONCLUSIONS: Our prospective study supports a role of low serum total and LDL-cholesterol and of oxidative stress as positive independent predictive factors of poor RVR in HCV patients. |
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Authors:
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F Angelico; S Francioso; M Del Ben; K Feole; M Carbone; P Pignatelli; F Violi; M Angelico |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-06-02 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 30 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-18 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 444-51 Citation Subset: IM |
Affiliation:
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Department of Experimental Medicine, Division of Internal Medicine C, Sapienza University, Rome, Italy. Francesco.angelico@uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antiviral Agents / therapeutic use* Cholesterol, LDL Female Hepacivirus / drug effects* Hepatitis C, Chronic / drug therapy*, virology Humans Male Middle Aged Oxidative Stress Polyethylene Glycols / administration & dosage* Predictive Value of Tests RNA, Viral / blood, drug effects* Ribavirin / therapeutic use* Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Cholesterol, LDL; 0/Polyethylene Glycols; 0/RNA, Viral; 36791-04-5/Ribavirin |
| Comments/Corrections | |
Comment In:
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Aliment Pharmacol Ther. 2010 Jan 15;31(2):339-40; author reply 340-1
[PMID:
20078498
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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