Document Detail


Clinical trial design: the neglected problem of asymmetrical transfer in cross-over trials.
MedLine Citation:
PMID:  6364197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paper illustrates drawbacks of the popular cross-over design in clinical trials in psychiatry where treatment effects become distorted by, and confounded with, the effects of their order of administration. It is argued that research workers should analyse data from cross-over trials for asymmetries due to order of treatment and seriously doubt the reliability of data if such effects are found. The problem is avoided by the use of separate-groups designs.
Authors:
K Millar
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Psychological medicine     Volume:  13     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-28     Completed Date:  1984-02-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  867-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Humans
Mental Disorders / drug therapy*,  psychology
Psychotropic Drugs / therapeutic use*
Research
Chemical
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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