Document Detail

Clinical trial design: the neglected problem of asymmetrical transfer in cross-over trials.
MedLine Citation:
PMID:  6364197     Owner:  NLM     Status:  MEDLINE    
The paper illustrates drawbacks of the popular cross-over design in clinical trials in psychiatry where treatment effects become distorted by, and confounded with, the effects of their order of administration. It is argued that research workers should analyse data from cross-over trials for asymmetries due to order of treatment and seriously doubt the reliability of data if such effects are found. The problem is avoided by the use of separate-groups designs.
K Millar
Related Documents :
12121967 - Hematologic effects of linezolid: summary of clinical experience.
25259557 - Vertebral osteolytic defect due to cellulose particles derived from gauze fibers after ...
18515887 - Cognitive-behavioural therapy for severe mental disorders: back to the future?
22892547 - Manager support for work-family issues and its impact on employee-reported pain in the ...
19568227 - Pancreatic neuropathy results in "neural remodeling" and altered pancreatic innervation...
22964127 - Radioiodine therapy for multinodular goiter.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Psychological medicine     Volume:  13     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-28     Completed Date:  1984-02-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  867-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Clinical Trials as Topic
Mental Disorders / drug therapy*,  psychology
Psychotropic Drugs / therapeutic use*
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mental illness and rehabilitation in early nineteenth-century Ireland: the case of Charles Stock.
Next Document:  Cellular radiation effects and hyperthermia cell cycle kinetics of radiation sensitive mutants of Sa...