Document Detail


The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology.
MedLine Citation:
PMID:  19814743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Wireless pH and pressure motility capsule (wireless motility capsule) technology provides a method to assess regional gastrointestinal transit times.
AIMS: To analyse data from a multi-centre study of gastroparetic patients and healthy controls and to compare regional transit times measured by wireless motility capsule in healthy controls and gastroparetics (GP).
METHODS: A total of 66 healthy controls and 34 patients with GP (15 diabetic and 19 idiopathic) swallowed wireless motility capsule together with standardized meal (255 kcal). Gastric emptying time (GET), small bowel transit time (SBTT), colon transit time (CTT) and whole gut transit time (WGTT) were calculated using the wireless motility capsule.
RESULTS: Gastric emptying time, CTT and WGTT but not SBTT were significantly longer in GP than in controls. Eighteen percent of gastroparetic patients had delayed WGTT. Both diabetic and idiopathic aetiologies of gastroparetics had significantly slower WGTT (P < 0.0001) in addition to significantly slower GET than healthy controls. Diabetic gastroparetics additionally had significantly slower CTT than healthy controls (P = 0.0054).
CONCLUSIONS: In addition to assessing gastric emptying, regional transit times can be measured using wireless motility capsule. The prolongation of CTT in gastroparetic patients indicates that dysmotility beyond the stomach in GP is present, and it could be contributing to symptom presentation.
Authors:
I Sarosiek; K H Selover; L A Katz; J R Semler; G E Wilding; J M Lackner; M D Sitrin; B Kuo; W D Chey; W L Hasler; K L Koch; H P Parkman; J Sarosiek; R W McCallum
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-10-08
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  31     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-07-30     Revised Date:  2012-03-05    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-22     Citation Subset:  IM    
Affiliation:
Center for Gastrointestinal Nerve & Muscle Function & GI Motility, University of Kansas Medical Center, Kansas City, USA. Irene.sarosiek@ttuhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Capsule Endoscopy / methods*
Colon / physiology*
Female
Gastrointestinal Motility / drug effects,  physiology*
Gastrointestinal Transit / physiology*
Gastroparesis / physiopathology*
Humans
Male
Middle Aged
Monitoring, Physiologic / methods
Grant Support
ID/Acronym/Agency:
DK069614/DK/NIDDK NIH HHS; K23 DK069614-05/DK/NIDDK NIH HHS

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