Document Detail

Clinical trial of allogeneic cultured dermal substitutes for intractable skin ulcers of the lower leg.
MedLine Citation:
PMID:  18604614     Owner:  NLM     Status:  MEDLINE    
The efficacy of allogeneic cultured dermal substitute (CDS) on wound healing was evaluated in six patients with intractable skin ulcers on the lower extremities. Allogeneic CDS was repeatedly applied to wounds at intervals of 4-7 days to prepare a wound bed acceptable for skin grafting or to induce resurfacing through the granulation tissue formation associated with epithelialization. In one patient with a leg ulcer, the wound size decreased to 32% of the original size within 10 weeks and skin grafting was conducted. In the other five patients with leg, ankle, or foot ulcers, the wound size decreased to 9%-25% of the original size within 6 weeks.
Naoto Yamada; Eiju Uchinuma; Yoshimitsu Kuroyanagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-06
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  11     ISSN:  1434-7229     ISO Abbreviation:  J Artif Organs     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  100-3     Citation Subset:  IM    
Department of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Japan.
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MeSH Terms
Cells, Cultured
Fibroblasts / cytology
Leg Ulcer / surgery*
Middle Aged
Tissue Engineering / methods*
Wound Healing

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