Document Detail

Clinical treatment of obesity: are drugs and surgery the answer?
MedLine Citation:
PMID:  15877924     Owner:  NLM     Status:  MEDLINE    
Obesity treatment remains a 'Cinderella' of all clinical management programmes, but generally without a happy ending. The great expectation for new therapeutic agents has not been fulfilled in clinical practice, whilst the restriction of eating through surgical division of the upper bowel seems strange in an age of advanced and sophisticated technology. The better understanding of the neuro-regulation of appetite, and its application as part of evidence-based clinical interventions, could lead to a more coherent approach to obesity treatment. Nevertheless, investigation of potential neuroendocrine targets for appetite suppression suggests redundancy in the systems, which make development of effective agents against single receptors impractical. Importantly, the progressive rise in the prevalence of obesity will inevitably mean that only a small proportion of afflicted patients will actually be treated by long-term drugs and surgery. Drugs and surgery are not currently the answer for the majority of obese individuals. What is required is a better way of identifying patients who may particularly benefit from such approaches. However, the major emphasis must be the development of effective population-wide interventions that halt the increase in fatness and ensure that future generations maintain and enjoy a healthy body weight.
Peter G Kopelman
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Publication Detail:
Type:  Lectures    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  64     ISSN:  0029-6651     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
Barts and the London, Queen Mary's School of Medicine & Dentistry, University of London, UK.
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MeSH Terms
Anti-Obesity Agents / therapeutic use*
Appetite Regulation / drug effects*
Life Style
Obesity / drug therapy*,  epidemiology,  surgery*
Treatment Outcome
Reg. No./Substance:
0/Anti-Obesity Agents

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