| Clinical toxicity of furosemide in hospitalized patients. A report from the Boston Collaborative Drug Surveillance Program. | |
| | |
MedLine Citation:
|
PMID: 868744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Of 17,068 hospitalized medical patients monitored in a drug surveillance program, 2,367 (13.9 per cent) received furosemide. Of these patients, 53 per cent were hospitalized with a primary (first) diagnosis of cardiovascular disease; many other patients had cardiovascular disorders coincident with other diseases. In 78 per cent of cases the indication for furosemide therapy was congestive heart failure. Adverse reactions were attributed to furosemide in 239 patients (10.1 per cent), but in only 14 instances were the unwanted effects considered life-threatening. The most common adverse reactions were: intravascular volume depletion (4.6 per cent of furosemide recipients), hypokalemia (3.6 per cent), and other eletrolyte disturbances (1.5 per cent). Many patients experienced more than one manifestation of toxicity. The over-all frequency of adverse reactions increased progressively with higher daily doses of furosemide, but was not correlated with total furosemide dose. Among furosemide recipients who also recieved potassium-supplements or potassium-sparing diuretics, hypokalemia was less frequent, less severe, and of slower onset. Coadministration of other diuretics with furosemide was associated with a higher frequency of volume depletion. The findings indicate that furosemide is a relatively safe diuretic in a wide range of clinical situations. Serious adverse reactions are uncommon, and occur primarily in the seriously ill. |
| | |
Authors:
|
D J Greenblatt; D W Duhme; M D Allen; J Koch-Weser |
Related Documents
:
|
2256494 - Neuroophthalmologic effects of intravenous magnesium sulfate. 2729314 - Dosing of contrast material to prevent contrast nephropathy in patients with renal dise... 596244 - Studies on digitalis. xiv. is there any correlation between hypomagnesemia and digitali... 22568544 - Pectus excavatum and mass phenotype: an unknown association. 19547834 - Angioarchitecture and clinical presentation of brain arteriovenous malformations. 19908144 - Adsorptive depletion of alpha4 integrin(hi)- and cx3cr1hi-expressing proinflammatory mo... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American heart journal Volume: 94 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1977 Jul |
Date Detail:
|
Created Date: 1977-07-29 Completed Date: 1977-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 6-13 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Canada Drug Information Services Drug Therapy, Combination Female Furosemide / adverse effects* Hospitalization Humans Israel Male Middle Aged New Zealand United States |
| Chemical | |
Reg. No./Substance:
|
54-31-9/Furosemide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of test site on ventricular fibrillation threshold.
Next Document: The thoracic windows for electrical ventricular defibrillation current.