Document Detail

Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin.
MedLine Citation:
PMID:  19146601     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several chemical agents are currently used to perform superficial peels of the face to reduce facial hyperpigmentation and fine lines/wrinkles. Some of the most commonly used agents are alpha hydroxyl acids, such as glycolic acid (GA), or beta hydroxy acid, such as salicylic acid. AIM: This study aims to compare the efficacy of GA to that of a novel derivative of salicylic acid, capryloyl salicylic acid (LHA). SUBJECTS/METHODS: In a split-face study, 50 female volunteers between the ages of 35 and 60 years with mild to moderate facial hyperpigmentation and fine lines/wrinkles were randomized and LHA or GA peel was applied to one side of the face. Increasing peel concentrations were applied (5-10% LHA or 20-50% GA) based on the tolerance level of the subjects and clinical observations of an expert dermatologist for 12 weeks at biweekly intervals. RESULTS: Of the 44 volunteers who completed the study, at 12 weeks 41% of LHA-treated and 30% of GA-treated subjects demonstrated significant reduction of fine lines/wrinkles compared to baseline. Forty-six percent of LHA-treated subjects and 34% of GA-treated subjects showed significant reduction of hyperpigmentation compared to baseline. LHA treatment was better than GA peels, although there were no statistically significant differences between the two groups. CONCLUSIONS: Five percent to 10% of LHA peel is generally safe and as effective as 20-50% GA peel in reducing facial hyperpigmentation and fine lines/wrinkles.
Christian Oresajo; Margarita Yatskayer; Isabelle Hansenne
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cosmetic dermatology     Volume:  7     ISSN:  1473-2165     ISO Abbreviation:  J Cosmet Dermatol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130964     Medline TA:  J Cosmet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
L'Oréal Research, Clark, NJ 07066, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Cutaneous
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  adverse effects,  therapeutic use*
Chemexfoliation / methods*
Drug Therapy, Combination
Glycolates / administration & dosage,  adverse effects,  therapeutic use*
Hydroxy Acids / administration & dosage,  adverse effects,  therapeutic use*
Hyperpigmentation / drug therapy*
Keratolytic Agents / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Patient Satisfaction
Salicylic Acids / administration & dosage,  adverse effects,  therapeutic use*
Single-Blind Method
Skin Aging / drug effects*
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Glycolates; 0/Hydroxy Acids; 0/Keratolytic Agents; 0/Salicylic Acids; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  New trends in face rejuvenation by hyaluronic acid injections.
Next Document:  A study to determine the efficacy of a novel handheld light-emitting diode device in the treatment o...