Document Detail

Clinical and therapeutic characterization of a Portuguese sample of patients with schizophrenia.
MedLine Citation:
PMID:  21560074     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The development of Mental Health policies for psychiatric disorders should be driven by a correct knowledge of the socio-demographic, clinical and therapeutic realities of the disease. There is paucity of detailed studies in the Portuguese population that does not allow a direct comparation with other European countries. The objective of the present study is to characterize the sociodemograhic and clinical characteristics of schizophrenia patients in Portugal and the therapeutic patterns.
METHODS: This multicentric, cross sectional, non interventional study was designed to describe the demographic and clinical data of patients with schizophrenia (n=474), and also the demographic and professional characteristics of their treating psychiatrists.
RESULTS: The most frequent diagnosis found was paranoid schizophrenia (54%), with comorbid psychiatric conditions in 39,7% and somatic diseases in 28.4% of the patients. About half the patients were on second generation antipsychotics (SGS) as principal therapy, although haloperidol has been the most frequent drug prescribed as so (35.9 %). 59.51 % of the patients were on antipsychotic monotherapy, and 45% on a depot formulation. Antipsychotic dose vary widely, and they are quite often prescribed on off label doses.
DISCUSSION: Our sample is similar to others found in naturalistic studies, however slightly different from clinical trials. In general, patients with schizophrenia tend to be treated with SGA, although have a higher chance to be on a long-term formulation and to be on polytherapy than in other studies. Somatic diseases are maybe under diagnosed and are undertreated.
Frederico Simões do Couto; Cristina Queiroz; Teresa Barbosa; Luis Ferreira; Horácio Firmino; Miguel Viseu; Luisa Ramos; Jose Romero; Maria Luisa Figueira;
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2011-05-01
Journal Detail:
Title:  Actas españolas de psiquiatría     Volume:  39     ISSN:  1578-2735     ISO Abbreviation:  Actas Esp Psiquiatr     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-08-03     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  100886502     Medline TA:  Actas Esp Psiquiatr     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Clínica Universitária de Psiquiatria Faculdade de Medicina de Lisboa Lisboa, Portugal Instituto de Farmacologia e Neurociencias Instituto de Medicina Molecular Lisboa, Portugal.
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MeSH Terms
Cross-Sectional Studies
Middle Aged
Schizophrenia / diagnosis*,  therapy*
Young Adult
Eurico Allen Revez / ; Teresa Babo / ; Teresa Barbosa / ; Teresa Cabral / ; Sílvia Castro / ; Rui Correia / ; Isabel Cruz / ; António José Daskalos / ; Maria Luísa Figueira / ; Zélia Figueiredo / ; José Manuel Jara / ; Luís Ferreira / ; António Marieiro / ; Amélia Martins / ; João Marques Teixeira / ; Vitor Oliveira / ; António Palha / ; Carlos Paz Ferreira / ; António Pissarra da Costa / ; María Clara Rosa / ; José Salgado / ; Érico da Silveira Alves / ; Jorge Tudela / ; María José Varanda / ; Adriano Vaz Serra / ; Miguel Viseu /

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