| Clinical testing of a new, low-flux polysulfone membrane. Results of a 26-week study. | |
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MedLine Citation:
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PMID: 2679793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a 6-month study, a new hollow-fiber (HF) dialyzer with a modified polysulfone (PS) membrane was evaluated in 12 hemodialysis patients. Seven of them had previously used a cuprophane (CU) HF and five a polymethylmethacrylate (PMMA) HF dialyzer. The PS dialyzer reduced the concentration of serum creatinine by 54 +/- 5% (SD), that of urea by 59 +/- 5%, that of urate by 62 +/- 6% and that of phosphate by 40 +/- 12%; the mean urea index (Kt/V) was 0.9. Heparin consumption diminished with the PS dialyzer compared with the PMMA dialyzer. The serum predialysis beta-2-microglobulin (beta 2M) concentrations rose by 5.4 mg/l (mean). The intradialytic beta 2M measurements showed insignificant changes in all the membranes studied. Eosinophilia was initially observed in 4/12 (33%) of the patients, all using an ethylene oxide (ETO)-sterilized CU dialyzer. At the end of the study this figure had decreased to 1/12 (8%). The serum IgE concentrations also decreased significantly. IgE class antibodies to ETO were initially detected in 2 patients. The level decreased clearly in 1 of them after switching to the PS dialyzer. The new PS dialyzer was found to be effective, possibly less allergenic and, owing to its moderate hydraulic permeability, suitable for routine dialyses. |
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Authors:
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E Honkanen; C Grönhagen-Riska; A M Teppo; U Hiltunen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood purification Volume: 7 ISSN: 0253-5068 ISO Abbreviation: Blood Purif. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-11-27 Completed Date: 1989-11-27 Revised Date: 2006-04-17 |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 240-6 Citation Subset: IM |
Affiliation:
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Helsinki University Central Hospital, Fourth Department of Medicine, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biocompatible Materials* Eosinophilia / blood Ethylene Oxide / immunology Female Humans Immunoglobulin E / metabolism Leukocyte Count Longitudinal Studies Male Membranes, Artificial* Middle Aged Platelet Count Polymers* Renal Dialysis / instrumentation* Sulfones* Urea / blood beta 2-Microglobulin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Membranes, Artificial; 0/Polymers; 0/Sulfones; 0/beta 2-Microglobulin; 25135-51-7/polysulfone P 1700; 37341-29-0/Immunoglobulin E; 57-13-6/Urea; 75-21-8/Ethylene Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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