Document Detail

Clinical and systemic hemodynamic effects of nitrendipine.
MedLine Citation:
PMID:  6734029     Owner:  NLM     Status:  MEDLINE    
The antihypertensive effects of nitrendipine were evaluated in 12 subjects with hypertension, one of whom could not tolerate the drug for more than 3 days; hence hemodynamics were studied in the 11 subjects who were treated for 2 wk. In one patient taking 40 mg twice a day, blood pressure reduction was associated with a hemodynamic pattern of hyperkinetic circulation. Of the other 10 subjects, all of whom were taking 20 mg twice a day, two did not respond, but 8 had significant reduction in mean arterial pressure (136 +/- 4.3 to 106 +/- 3.2 mm Hg) resulting from a decrease in total peripheral resistance (52 +/- 3.7 to 35 +/- 2.6 U X m2). Changes in cardiac output, heart rate, and cardiopulmonary volume varied widely among subjects, such that average changes did not attain significance. Heart rate and cardiopulmonary volume, however, changed in the same direction, which suggests that the alterations in both were related to the degree of reflex sympathetic stimulation induced by nitrendipine. Plasma renin activity (PRA) increased during treatment (2.6 +/- 1.0 to 9.3 +/- 4.1 ng/ml/hr), whereas the increase in plasma aldosterone (PA) levels did not attain significance (13.7 +/- 1.6 to 21.5 +/- 4.5 ng/dl). As a result, PA/PRA decreased (16.1 +/- 4.9 to 9.4 +/- 2.6). These results suggest that calcium entry blockade might have interfered with steroidogenesis, thus blunting the effect of increased PRA. Finally, blood pressure response to nitrendipine in the whole group correlated inversely with pretreatment PRA (r = -0.88), suggesting greater activity of the drug in low-renin hypertension.
F M Fouad; R Pedrinelli; E L Bravo; F Abi-Samra; S C Textor; R C Tarazi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  35     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-08-01     Completed Date:  1984-08-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  768-75     Citation Subset:  AIM; IM    
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MeSH Terms
Antihypertensive Agents / adverse effects,  pharmacology*
Blood Pressure / drug effects
Blood Volume / drug effects
Cardiac Output / drug effects
Dose-Response Relationship, Drug
Drug Evaluation
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy
Middle Aged
Nifedipine / adverse effects,  analogs & derivatives*,  pharmacology
Renin-Angiotensin System / drug effects
Tachycardia / chemically induced
Reg. No./Substance:
0/Antihypertensive Agents; 21829-25-4/Nifedipine; 39562-70-4/Nitrendipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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