| Clinical syndromes of hormone receptor mutations: hormone resistance and independence. | |
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MedLine Citation:
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PMID: 8068885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical syndromes of hormone resistance or independence have baffled clinicians for decades. These syndromes sometimes result from mutations or deficiencies in enzymes that activate prohormones or from alterations in signal transduction proteins. The majority of these conditions, however, arise from abnormalities of hormone receptors. We describe examples of syndromes that result from genetic mutations or misexpression of steroid/thyroid hormone receptors, with a specific emphasis on thyroid and androgen resistance syndromes, and estrogen independence in breast cancer. |
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Authors:
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R J Auchus; S A Fuqua |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in cell biology Volume: 5 ISSN: 1043-4682 ISO Abbreviation: Semin. Cell Biol. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-09-29 Completed Date: 1994-09-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9007587 Medline TA: Semin Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 127-36 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Wilford Hall Medical Center, Lackland AFB, TX 78236. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endocrine System Diseases / etiology, genetics* Hormones / physiology Humans Mutation* Receptors, Steroid / genetics* Receptors, Thyroid Hormone / genetics* Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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CA 30195/CA/NCI NIH HHS; CA 52351/CA/NCI NIH HHS; P30 CA 54174/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 0/Receptors, Steroid; 0/Receptors, Thyroid Hormone |
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