| Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005. | |
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MedLine Citation:
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PMID: 17335633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing Escherichia coli (VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders. |
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Authors:
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K G J Pollock; D Young; T J Beattie; W T A Todd |
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Publication Detail:
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Type: Journal Article Date: 2007-03-05 |
Journal Detail:
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Title: Epidemiology and infection Volume: 136 ISSN: 0950-2688 ISO Abbreviation: Epidemiol. Infect. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-19 Completed Date: 2008-02-29 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 8703737 Medline TA: Epidemiol Infect Country: England |
Other Details:
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Languages: eng Pagination: 115-21 Citation Subset: IM |
Affiliation:
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Health Protection Scotland, Glasgow, Scotland, UK. Kevin.Pollock@hps.scot.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Databases, Factual Escherichia coli / isolation & purification, metabolism Escherichia coli O157 / isolation & purification Female Hemolytic-Uremic Syndrome / blood, epidemiology*, etiology, microbiology, pathology Humans Length of Stay / statistics & numerical data* Male Middle Aged Population Surveillance Prospective Studies Purpura, Thrombocytopenic / blood, epidemiology*, etiology, microbiology, pathology Questionnaires Scotland / epidemiology Sex Factors Shiga Toxins / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Shiga Toxins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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