Document Detail

Clinical success of intrauterine insemination cycles is affected by the sperm preparation time.
MedLine Citation:
PMID:  24745729     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To determine the impact of the time interval from the end of sperm preparation (TSP) to intrauterine insemination (IUI) on the outcome.
DESIGN: Prospective multicentre cohort study.
SETTING: Seven French centers (assisted reproduction group in northeastern France, four academic centers, and three clinics).
PATIENT(S): Eight hundred sixty-two IUI cycles (709 patients) managed by gonadotropins were studied.
INTERVENTION(S): Cycles were stimulated by either FSH or hMG, and hCG was administrated when the leading follicle diameter measured >15 mm. IUIs were performed ∼36 hours after ovulation triggering.
MAIN OUTCOME MEASURE(S): Generalized linear mixed models for binary outcomes were used to model clinical pregnancy (CP) to assess the effect of TSP adjusted for other predictors (such as maternal age, semen quality, and indication of IUI treatment).
RESULT(S): The TSP effect was significant, featuring an inverse U-shaped curve admitting an optimum interval of ∼40-80 minutes improving CP compared with other values. Other significant predictors were total motile spermatozoa inseminated, maternal age, and unexplained infertility.
CONCLUSION(S): The observance of TSP in the range of 40-80 minutes has a potential positive effect on pregnancy rate, while not requiring the investment of supplemental resources. This finding awaits confirmation in randomized trials.
Patricia Fauque; Philippe Lehert; Marjorie Lamotte; Karima Bettahar-Lebugle; Alphée Bailly; Catherine Diligent; Michel Clédat; Paul Pierrot; Marie-Lorraine Guénédal; Paul Sagot
Related Documents :
23183399 - Hypertriglyceridemia-induced acute pancreatitis in pregnancy.
24882879 - Cervical carcinoma in early pregnancy - successful birth by caesarean section followed ...
23220269 - Outcomes in cephalic versus non-cephalic presentation in the setting of preterm prematu...
25136169 - Trends in cesarean delivery: rate and indications.
24639809 - Perinatal outcomes of pregnancies with borderline versus normal amniotic fluid index.
24591959 - Successful outcome in preeclamptic rudimentary horn pregnancy.
11316929 - First trimester diagnosis of split hand/foot by transvaginal ultrasound.
23413819 - Prediction of outcome in twin pregnancy with first and early second trimester ultrasound.
2467849 - Outcome of pregnancy in relation to maternal serum alpha-fetoprotein levels in the seco...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-16
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evaluation of the Performance of a Rapid Enzyme-Linked Immunosorbent Assay in the Detection of Anapl...
Next Document:  Requirement of heart and neural crest derivatives-expressed transcript 2 during decidualization of h...