Document Detail

Clinical study of upper gastrointestinal bleeding associated with low-dose aspirin in Japanese patients.
MedLine Citation:
PMID:  20214214     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The aim of this study was to clarify the prevalence and various clinical factors of upper gastrointestinal bleeding (UGIB) associated with low-dose aspirin (LDA) treatment. METHODOLOGY: There were 6,807 patients who were under treatment with LDA at our hospital between January 2003 and November 2007. They had kept taking the LDA or started treatment in the study period and kept taking the whole period of observation. Esophagogastroduodenoscopy (EGD) was performed 453 patients of these patients, and 71 were diagnosed as LDA-associated UGIB. We examined the prevalence and various clinical factors of UGIB associated with LDA treatment. RESULTS: The occurrence rate of UGIB was 0.209 UGIB per 100 patient-years at least. The multivariate odds ratio of LDA-associated UGIB was 3.318 (95% confidence interval (CI) 1.650-6.671, p = 0.0008) for a history of peptic ulcer, 0.086 (95% CI: 0.011-0.652, p = 0.0176) for the use of a proton pump inhibitor (PPI) with LDA, and 0.253 (95% CI: 0.113-0.569, p = 0.0009) for the use of a histamine type 2 receptor antagonist (H2RA) with LDA. CONCLUSIONS: Our results suggest that a history of peptic ulcer significantly increases the risk of LDA-associated UGIB. Regular use of a PPI or a H2RA effectively decreases the risk.
Kazuhisa Okada; Masahiko Inamori; Kento Imajo; Hideyuki Chiba; Takashi Nonaka; Tadahiko Shiba; Takashi Sakaguchi; Kazuhiro Atsukawa; Hisao Takahashi; Etsuo Hoshino; Atsushi Nakajima
Related Documents :
3573184 - Clinical significance of hematuria in patients on anticoagulant therapy.
23617744 - An international longitudinal registry of patients with atrial fibrillation at risk of ...
2284984 - Clinical and long-term follow-up study in patients with spontaneous subarachnoid haemor...
22407044 - Audiometric evaluation of patients treated for pulmonary tuberculosis.
17273134 - Management of gastro-esophageal reflux disease in primary care. results from an observa...
22686564 - The controversies of diagnosing and treating hypertension among hemodialysis patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  56     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1665-9     Citation Subset:  IM    
Division of Gastroenterology, Hiratsuka City Hospital, Hiratsuka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Aspirin / adverse effects*
Gastrointestinal Hemorrhage / chemically induced*
Middle Aged
Multivariate Analysis
Peptic Ulcer / complications
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Morphological criteria for metastatic mesorectal lymph nodes in rectal cancer.
Next Document:  Assessing the interstitial cells of Cajal, cells of enteric nervous system and neurotransmitters in ...