Document Detail

Clinical study on the treatment of knee osteoarthritis of Shen-Sui insufficiency syndrome type by electroacupuncture.
MedLine Citation:
PMID:  20697938     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the clinical effificacy of electroacupuncture (EA) on treating knee osteoarthritis (KOA) of Shen ()-Sui () insuffificiency (SSI) syndrome type.
METHODS: A total of 245 patients (279 knees) of KOA-SSI were randomly assigned to two groups by lottery: 141 knees in the treatment group and 138 knees in the control group. The treatment group was managed with EA at the dominant points of Neixiyan (Ex-LE4) and Waixiyan (Ex-LE5) as well as the conjugate points of Xuanzhong (GB39) and Taixi (KI3) for 30 min, once a day, with 15 days as one course; 2 courses were applied with a 5-day interval in between. The control group was treated with intra-articular injection of 2 mL hyaluronic acid into the affected joint every 7 days for 5 times in total. The clinical effects on the patients in different stages were observed, and their symptom scores of knee and contents of cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E(2alpha) (PGE(2alpha)) and matrix metalloproteinases-3 (MMP-3), in the knee joint fluid were measured before and after treatment.
RESULTS: The study was completed in 235 patients (263 knees); four patients (7 knees) in the treatment group and six patients (9 knees) in the control group dropped out. Comparison of therapeutic effects (excellent and effective rates) between the two groups showed insignificant differences (P>0.05). Symptom scores of knee and contents of cytokines in the knee flfluid after treatment were lowered signifificantly in the patients of stage I-III in both groups (P<0.05 or P<0.01). However, the lowering of the total symptom score of knee in the patients of stage III in the treatment group was more signifificant (P<0.05).
CONCLUSIONS: EA could effectively alleviate the clinical symptoms in KOA patients of stage III, showing an effect superior to that of hyaluronic acid. EA also shows action in suppressing the secretion of IL-1, IL-6, TNF-alpha, PGE(2alpha) and MMP-3 in the knee flfluid.
Ming-xia Wu; Xi-hai Li; Mu-nan Lin; Xi-rui Jia; Rong Mu; Wen-rong Wan; Rui-hua Chen; Li-hua Chen; Wan-qing Lin; Cong-yang Huang; Xue-ru Zhang; Kun-da Hong; Li Li; Xian-xiang Liu
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-10
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  16     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350003, China.
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MeSH Terms
Cytokines / metabolism
Electroacupuncture / adverse effects,  methods*
Matrix Metalloproteinase 3 / metabolism
Middle Aged
Osteoarthritis, Knee / enzymology,  radiography,  therapy*
Synovial Fluid / enzymology
Treatment Outcome
Reg. No./Substance:
0/Cytokines; EC Metalloproteinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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