Document Detail


Clinical study on safety and efficacy of the administration of amlodipine in a combination with lisinopril in hypertensive patients.
MedLine Citation:
PMID:  16268059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Evaluation of efficacy and safety of long-term (24 weeks) administration of a combined therapy of ACE inhibitors (lisinopril) and calcium-channel antagonists with long-term action (amlodipine) (with or without diuretics). METHOD: A total number of 98 patients of both genders were included in the prospective, open trial. Evaluation of efficacy of the trial was carried out by careful monitoring of anamnesis and physical examination, blood-pressure values, pulse, body weight, ECG test and echocardiographic test. Evaluation of safety of the trial was based on the evaluation of a physician, standard laboratory evaluation, adverse effects. RESULT: Mean value of blood pressure in the beginning of clinical trial was significantly reduced (from 197.65 +/- 18.05/107.1+/-13.1 mm Hg, to 139.85 +/-10.45/82.6+/-5.47 mmHg) after 24 weeks, without special oscillations in last three months. The pulse remained within physiological limits. In 73.08% patients, echocardiographic test has proven an improvement of ejection fraction. Minor adverse effects have been reported, which were not a reason for interruption of the treatment, with the exception of 3 cases (lower leg oedema, dry cough). CONCLUSION: An extremely good effect in patients with moderate hypertension was reported in the trial, as well as in patients with severe hypertension with good tolerance.
Authors:
Amila Arslanagic; Irfan Zulic; Azra Bajraktarevic
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Medicinski arhiv     Volume:  59     ISSN:  0350-199X     ISO Abbreviation:  Med Arh     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-04     Completed Date:  2005-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400722     Medline TA:  Med Arh     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  IM    
Affiliation:
Clinic for Cardiac Diseases and Rheumatism of University Clinical Centre in Sarajevo.
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MeSH Terms
Descriptor/Qualifier:
Amlodipine / administration & dosage*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects
Calcium Channel Blockers / administration & dosage*
Drug Therapy, Combination
Humans
Hypertension / drug therapy*,  physiopathology
Lisinopril / administration & dosage*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 83915-83-7/Lisinopril; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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