| Clinical study on pulmonary diffusion function in patients with chronic liver disease. | |
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MedLine Citation:
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PMID: 20883425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the influence of chronic liver disease (CLD) on pulmonary diffusion function. METHODS: Arterial blood gas analysis, pulmonary function test, contrast-enhanced transthoracic echocardiography and technetium macro-aggregated albumin scanning were performed in 50 cirrhotic patients who underwent surgery on portal hypertension and liver transplantation. The severity of chronic liver disease (CLD) was evaluated by Child-Pugh-Turcotte (CPT) categorization and model for end stage liver disease (MELD) score from October 2008 to July 2009 in our surgical department and organ transplantation center. RESULTS: A-aDO(2) was increased with the aggravation of liver dysfunction. The pulmonary diffusion capacity for carbon monoxide (DLCO) differed significantly among the three groups, which was (90.8 ± 7.3)% in CPT A group, (82.8 ± 10.8)% in CPT B group, and (73.5 ± 8.3)% in CPT C group. A-aDO(2) correlated positively with CPT (r= 0.581, P= 0.000) as well as the MELD score (r= 0.696, P= 0.000), whereas DLCO was negatively correlated with CPT (r=-0.630, P= 0.000) and the MELD score (r=-0.708, P= 0.000). CONCLUSION: DLCO can be useful in the detection of pulmonary vascular abnormality of CLD. The MELD score may be a better criterion than the CPT score in assessing intrapulmonary vascular damage of CLD patients. |
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Authors:
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Yan Miao Huo; Rong Hua; Wei Chen; Yong Wei Sun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of digestive diseases Volume: 11 ISSN: 1751-2980 ISO Abbreviation: J Dig Dis Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101302699 Medline TA: J Dig Dis Country: Australia |
Other Details:
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Languages: eng Pagination: 291-8 Citation Subset: IM |
Copyright Information:
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© 2010 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chronic Disease End Stage Liver Disease / physiopathology Female Humans Liver Diseases / physiopathology* Male Middle Aged Oxygen / blood Pulmonary Diffusing Capacity* Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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