Document Detail

Clinical study on pulmonary diffusion function in patients with chronic liver disease.
MedLine Citation:
PMID:  20883425     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the influence of chronic liver disease (CLD) on pulmonary diffusion function.
METHODS: Arterial blood gas analysis, pulmonary function test, contrast-enhanced transthoracic echocardiography and technetium macro-aggregated albumin scanning were performed in 50 cirrhotic patients who underwent surgery on portal hypertension and liver transplantation. The severity of chronic liver disease (CLD) was evaluated by Child-Pugh-Turcotte (CPT) categorization and model for end stage liver disease (MELD) score from October 2008 to July 2009 in our surgical department and organ transplantation center.
RESULTS: A-aDO(2) was increased with the aggravation of liver dysfunction. The pulmonary diffusion capacity for carbon monoxide (DLCO) differed significantly among the three groups, which was (90.8 ± 7.3)% in CPT A group, (82.8 ± 10.8)% in CPT B group, and (73.5 ± 8.3)% in CPT C group. A-aDO(2) correlated positively with CPT (r= 0.581, P= 0.000) as well as the MELD score (r= 0.696, P= 0.000), whereas DLCO was negatively correlated with CPT (r=-0.630, P= 0.000) and the MELD score (r=-0.708, P= 0.000).
CONCLUSION: DLCO can be useful in the detection of pulmonary vascular abnormality of CLD. The MELD score may be a better criterion than the CPT score in assessing intrapulmonary vascular damage of CLD patients.
Yan Miao Huo; Rong Hua; Wei Chen; Yong Wei Sun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  11     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  291-8     Citation Subset:  IM    
Copyright Information:
© 2010 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, China.
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MeSH Terms
Chronic Disease
End Stage Liver Disease / physiopathology
Liver Diseases / physiopathology*
Middle Aged
Oxygen / blood
Pulmonary Diffusing Capacity*
Severity of Illness Index
Reg. No./Substance:

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