Document Detail


Clinical study on pulmonary diffusion function in patients with chronic liver disease.
MedLine Citation:
PMID:  20883425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the influence of chronic liver disease (CLD) on pulmonary diffusion function.
METHODS: Arterial blood gas analysis, pulmonary function test, contrast-enhanced transthoracic echocardiography and technetium macro-aggregated albumin scanning were performed in 50 cirrhotic patients who underwent surgery on portal hypertension and liver transplantation. The severity of chronic liver disease (CLD) was evaluated by Child-Pugh-Turcotte (CPT) categorization and model for end stage liver disease (MELD) score from October 2008 to July 2009 in our surgical department and organ transplantation center.
RESULTS: A-aDO(2) was increased with the aggravation of liver dysfunction. The pulmonary diffusion capacity for carbon monoxide (DLCO) differed significantly among the three groups, which was (90.8 ± 7.3)% in CPT A group, (82.8 ± 10.8)% in CPT B group, and (73.5 ± 8.3)% in CPT C group. A-aDO(2) correlated positively with CPT (r= 0.581, P= 0.000) as well as the MELD score (r= 0.696, P= 0.000), whereas DLCO was negatively correlated with CPT (r=-0.630, P= 0.000) and the MELD score (r=-0.708, P= 0.000).
CONCLUSION: DLCO can be useful in the detection of pulmonary vascular abnormality of CLD. The MELD score may be a better criterion than the CPT score in assessing intrapulmonary vascular damage of CLD patients.
Authors:
Yan Miao Huo; Rong Hua; Wei Chen; Yong Wei Sun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  11     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  291-8     Citation Subset:  IM    
Copyright Information:
© 2010 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chronic Disease
End Stage Liver Disease / physiopathology
Female
Humans
Liver Diseases / physiopathology*
Male
Middle Aged
Oxygen / blood
Pulmonary Diffusing Capacity*
Severity of Illness Index
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

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