| Clinical study of [123I] N-(2-diethylaminoethyl)-4-iodobenzamide in the diagnosis of primary and metastatic ocular melanoma. | |
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MedLine Citation:
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PMID: 9541435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the value of scintigraphy with [123I]N-(2-diethylaminoethyl)-4-iodobenzamide (BZA), a phase II clinical trial was performed on 48 patients with a suspicion of ocular melanoma. METHODS: 56 examinations were performed to image lesions with a clinical diagnosis of primary ocular melanoma before and/or after treatment, to observe the results in simulating lesions or to image metastases. RESULTS: Ocular BZA-scintigraphy demonstrated a sensitivity of 86%, and a specificity of 83%. Whole-body scintigraphy was used in the follow-up of treated patients and could be repeated. We imaged orbital recurrence, known and occult metastases, specially in the liver. After 9 conservative treatments ocular BZA-scintigraphy was negative in 9 eyes. CONCLUSION: The BZA-scintigraphy in combination with other diagnostic procedures appeared to be a suitable method in the diagnosis of ocular melanoma and a potentially useful imaging modality to screen for ocular malignant melanoma metastases. |
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Authors:
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F Bacin; J Michelot; J Bonafous; A Veyre; M F Moreau; J L Kemeny; F Chossat; D Bekhechi |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Journal Article |
Journal Detail:
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Title: Acta ophthalmologica Scandinavica Volume: 76 ISSN: 1395-3907 ISO Abbreviation: Acta Ophthalmol Scand Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-05-05 Completed Date: 1998-05-05 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 9507578 Medline TA: Acta Ophthalmol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 56-61 Citation Subset: IM |
Affiliation:
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CHU Gabriel Montpied, Service d'Ophtalmologie, Clermont-Ferrand, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Benzamides / diagnostic use* Brachytherapy Conjunctival Neoplasms / pathology, radionuclide imaging*, therapy Contrast Media* Eye Enucleation Female Humans Laser Coagulation Liver Neoplasms / radionuclide imaging*, secondary, therapy Lung Neoplasms / radionuclide imaging*, secondary, therapy Male Melanoma / radionuclide imaging*, secondary, therapy Middle Aged Sensitivity and Specificity Uveal Neoplasms / pathology, radionuclide imaging*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/Contrast Media; 106790-96-9/N-(2-(diethylamino)ethyl)-4-iodobenzamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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