Document Detail

Clinical studies of tracheal gas insufflation.
MedLine Citation:
PMID:  11175244     Owner:  NLM     Status:  MEDLINE    
Tracheal gas insufflation (TGI) is an adjunct to mechanical ventilation that allows ventilation with small tidal volumes while carbon dioxide (CO2) is satisfactorily cleared. Pioneering studies in healthy animals and in humans suffering respiratory failure showed that the expiratory flushing of proximal dead space decreased minute ventilation with no change in arterial partial pressure of carbon dioxide (PaCO2). Recent work indicates that conventional mechanical ventilation aided by TGI may represent a novel ventilatory strategy that succeeds in limiting both the distending forces acting on the lungs and the PaCO2 elevation of permissive hypercapnia. Furthermore, some studies suggest that weaning aided by TGI may allow a reduction in minute ventilation, PaCO2, physiologic dead space, and the patient's respiratory demands. Clinical use of TGI requires careful monitoring of delivered volumes and pressures to ensure safe clinical application and to evaluate the effect on lung function. Finally, routine use of TGI in intensive care warrants further investigation to solve some technical problems and randomized clinical trials to confirm the beneficial effects in the absence of complications.
L L Blanch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Respiratory care     Volume:  46     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-66     Citation Subset:  IM    
Intensive Care Department, Hospital de Sabadell, Corporacio Parc Tauli, Parc Tauli s/n, 08208 Sabadell, Spain.
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MeSH Terms
Carbon Dioxide / physiology
Insufflation / adverse effects,  methods*
Intubation, Intratracheal*
Pulmonary Gas Exchange
Respiration, Artificial / adverse effects,  methods*
Respiratory Distress Syndrome, Adult / physiopathology,  therapy
Respiratory Insufficiency / physiopathology,  therapy
Ventilator Weaning
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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