| Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects. | |
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MedLine Citation:
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PMID: 7960020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adrenomedullin is a novel hypotensive peptide, newly discovered in pheochromocytoma. Because immunoreactive adrenomedullin is present in human plasma, adrenomedullin may play a role in regulating blood pressure. A recent report showed that human adrenomedullin mRNA is expressed not only in pheochromocytoma but also in the normal adrenal medulla, kidney, lung, and ventricle. However, whether or not these organs actually release adrenomedullin into the circulation remains unknown. To investigate the sites of production and degradation of adrenomedullin in human subjects, we obtained blood samples from various sites and measured immunoreactive adrenomedullin concentrations. In study 1, blood samples were obtained from the infrarenal inferior vena cava, suprarenal inferior vena cava, superior vena cava, right atrium, right ventricle, pulmonary artery, pulmonary capillary, left ventricle, and aorta during cardiac catheterization in 15 patients with ischemic heart disease (67 +/- 10 years). In study 2, blood samples were taken from the infrarenal inferior vena cava, suprarenal inferior vena cava, right and left renal veins, and left adrenal vein in 5 hypertensive patients (42 +/- 14 years) suspected of having renovascular hypertension. In study 3, peripheral venous blood samples were obtained in 2 patients (males, 45 and 36 years old) with pheochromocytoma at rest and during hypertensive attacks. Plasma adrenomedullin concentrations were measured by a newly developed radioimmunoassay. In study 1, there were no significant differences in plasma adrenomedullin concentrations in various sites of the right-side circulation. There was no step-up of plasma adrenomedullin levels in the coronary sinus. However, the plasma concentration of adrenomedullin in aorta was slightly but significantly lower than in pulmonary artery.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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T Nishikimi; K Kitamura; Y Saito; K Shimada; T Ishimitsu; M Takamiya; K Kangawa; H Matsuo; T Eto; T Omae |
Publication Detail:
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Type: Case Reports; Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 24 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 600-4 Citation Subset: IM |
Affiliation:
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Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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blood,
metabolism,
physiopathology* Adrenal Medulla / metabolism Adrenomedullin Adult Aged Antihypertensive Agents* Blood Pressure Epinephrine / blood Female Gene Expression Heart Rate Heart Ventricles Humans Hypertension / blood, metabolism, physiopathology* Kidney / metabolism Lung / metabolism Male Metabolic Clearance Rate Middle Aged Myocardial Ischemia / blood, metabolism, physiopathology* Myocardium / metabolism Norepinephrine / blood Peptide Biosynthesis* Peptides / blood* Pheochromocytoma / blood, metabolism, physiopathology* Pulmonary Artery / physiopathology Pulmonary Circulation RNA, Messenger / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Peptides; 0/RNA, Messenger; 148498-78-6/Adrenomedullin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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