Document Detail


Clinical studies of the reactivity of serum IgG from patients with Graves' ophthalmopathy with porcine orbital tissue preparations.
MedLine Citation:
PMID:  2631976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical utility of ELISA assays for antibodies reactive with a variety of porcine orbital tissue antigen preparations is described using sera from large numbers of patients. Use of such assays does not allow reliable identification of patients with Graves' ophthalmopathy (GO) due to the overlap between patients with and without eye involvement and normal individuals. In 5/6 patients showing high levels of reactivity with porcine eye muscle membrane antigen, a considerable but variable proportion of the binding was found to be species, rather than tissue, specific. No consistent pattern of change in ELISA reactivity with time was seen in studies of serum samples from patients treated medically for hyperthyroidism and patients who received immunosuppressive therapy with cyclosporin A for active, severe ophthalmopathy. Use of previously published ELISA methods using the crude antigen preparations described is therefore not likely to be of use in the routine clinical management of GO patients.
Authors:
R M Pope; A M McGregor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  43     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-14     Completed Date:  1990-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  573-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, King's College School of Medicine, Denmark Hill, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Antigen-Antibody Reactions
Connective Tissue / immunology
Cyclosporins / therapeutic use
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Graves Disease / drug therapy,  immunology*
Humans
Immunoglobulin G / immunology*
Male
Middle Aged
Orbit / immunology
Swine / immunology
Chemical
Reg. No./Substance:
0/Cyclosporins; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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