| Clinical studies of acute myeloid leukemia in the Japan Adult Leukemia Study Group. | |
| | |
MedLine Citation:
|
PMID: 22851055 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Acute myeloid leukemia (AML) is the most common adult leukemia in Japan. The treatment for AML consists of induction, consolidation, and maintenance therapies. To improve outcomes in the treatment of AML, the Japan Adult Leukemia Study Group has conducted six studies in AML patients aged 15-64 years since 1987. In AML201 study, IDR (12 mg/m(2)/day for 3 days) or DNR (50 mg/m(2)/day for 5 days) in combination with Ara-C (100 mg/m(2)/day continuous infusion for 7 days) was established as the standard induction therapy, and four courses of combination chemotherapy using non-cross-resistant agents for non-core binding factor (CBF) AML or three courses of high-dose Ara-C for CBF AML was established as the standard consolidation therapy. The AML97 study showed that allo-HSCT from an HLA-identical sibling donor reduced relapse incidence and improved disease-free survival (DFS), but did not significantly impact overall survival (OS) in poor or intermediate risk patients. Despite these studies by JALSG, only about one-third of AML patients remain free of disease for more than 7 years. The JALSG is now conducting the AML209 study to adapt individual therapies according to genetic alterations. |
| | |
Authors:
|
Shuichi Miyawaki |
Related Documents
:
|
22824185 - Allogeneic hematopoietic stem cell transplantation in adolescent and adult patients wit... 22853875 - A nomogram associated with high probability of malignant nodes in the surgical specimen... 22392525 - Burkitt post-transplantation lymphoma in adult solid organ transplant recipients: seque... 22679425 - Successful treatment of advanced ovarian cancer with thermochemotherapy and adjuvant im... 11720755 - Surgical treatment of stage iii non-small cell lung cancer. 1827305 - Carboplatin and cyclophosphamide salvage therapy for ovarian cancer patients relapsing ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-2 |
Journal Detail:
|
Title: International journal of hematology Volume: - ISSN: 1865-3774 ISO Abbreviation: Int. J. Hematol. Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Hematology, Tokyo Metropolitan Ohtsuka Hospital, 2-8-1 Minamiohtsuka, Toshima-ku, Tokyo, 170-8476, Japan, miyawaki@mail.wind.ne.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinetics and stereochemistry of hydrolysis of an N-(phenylacetyl)-?-hydroxyglycine ester catalyzed b...
Next Document: Prolonged remission from eltrombopag in chronic refractory idiopathic thrombocytopenic purpura.