Document Detail

Clinical status and acid-base balance during biofiltration in patients with acetate dialysis intolerance.
MedLine Citation:
PMID:  3557662     Owner:  NLM     Status:  MEDLINE    
Nine patients intolerant to acetate hemodialysis were treated with biofiltration. This consisted in a 4-h acetate hemodialysis during which an additional 2 liters of ultrafiltrate were replaced by a bicarbonate solution (100 mEq/l). Hypotensive episodes disappeared and six out of nine patients were symptom-free during the session. Compared to standard hemodialysis, arterial blood bicarbonate and pO2 did not drop during biofiltration. The anion gap did not change during standard hemodialysis, but was significantly reduced during biofiltration (24.5 +/- 2.9 vs 19.9 +/- 1.4 mEq/l). In our conditions clinical results were positive with biofiltration. On the basis of anion gap changes and preliminary results of plasma acetate determinations, it is suggested that a better cellular metabolism of acetate may be induced by bicarbonate infusion.
G Panzetta; N Tessitore; E Valvo; A Lupo; C Loschiavo; A Fabris; L Oldrizzi; R Panebianco; C Rugiu; Z Bellotti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  9 Suppl 3     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-11     Completed Date:  1987-05-11     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
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MeSH Terms
Acetates / administration & dosage
Acid-Base Equilibrium*
Blood Chemical Analysis
Blood Gas Analysis
Cellulose / analogs & derivatives
Hypotension / prevention & control
Membranes, Artificial
Middle Aged
Renal Dialysis / adverse effects*
Ultrafiltration / methods*
Reg. No./Substance:
0/Acetates; 0/Membranes, Artificial; 9004-34-6/Cellulose; 9050-09-3/cuprammonium cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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