Document Detail


[Clinical spectrum of tako-tsubo cardiomyopathy in Germany: results of the tako-tsubo registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK)].
MedLine Citation:
PMID:  20859840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tako-tsubo cardiomyopathy (TTC) was first described in 1990 in Japan. A TTC registry was initiated by the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK) in order to evaluate the clinical spectrum and the management of patients with this syndrome in Germany. METHODS: Patients from 37 hospitals were included in the registry if they fulfilled the following criteria: 1. acute chest symptoms or syncope, 2. new ischemic ECG changes with ST-segment elevation ± T-wave inversion, 3. reversible left ventricular regional wall motion abnormality not corresponding to a single coronary artery territory, 4. absence of significant coronary artery stenoses. RESULTS: 296 of the 324 patients (age 68 ±  12) were women (91 %) and 28 men (9 %). Leading symptoms were angina pectoris (72 %), dyspnoea (16 %), syncope (3 %) or resuscitation/cardiogenic shock (2 %). An antecedent trigger was found in 77  %. Time from symptom onset to hospital admission was 7,6  ±  6,9 hours. An acute coronary syndrome (ACS) was clinically suspected in 87 %. The ECG showed ST-segment elevation in 85 %. Cardiac troponin was elevated in more than 90 % of patients. Left ventricular ejection fraction by angiography was reduced to 49 ± 14 %. Initial medical treatment corresponded to the working diagnosis of an ACS. Catecholamines or an intraaortic balloon pump were necessary in 5 % and 1 %, respectively. Seven patients (2.2 %) died in hospital. CONCLUSION: TTC afflicts mainly women and presents clinically as an ACS in 87 %. Hospital mortality is low with symptomatic therapy.
Authors:
B Schneider; A Athanasiadis; J Schwab; W Pistner; W von Scheidt; U Gottwald; R Schamberger; R Schoeller; A Bublak; W Toepel; K D Winter; U Sechtem
Publication Detail:
Type:  English Abstract; Journal Article     Date:  2010-09-21
Journal Detail:
Title:  Deutsche medizinische Wochenschrift (1946)     Volume:  135     ISSN:  1439-4413     ISO Abbreviation:  Dtsch. Med. Wochenschr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006723     Medline TA:  Dtsch Med Wochenschr     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  1908-13     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Klinik für Kardiologie, Sana Kliniken Lübeck GmbH, Lübeck. b.schneider@sana-luebeck.de
Vernacular Title:
Klinische Versorgung von Patienten mit Tako-Tsubo-Kardiomyopathie: Ergebnisse des Tako-Tsubo-Registers der ALKK.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / diagnosis,  epidemiology,  etiology
Adult
Aged
Aged, 80 and over
Coronary Angiography
Creatine Kinase / blood
Cross-Sectional Studies
Diagnosis, Differential
Electrocardiography
Female
Germany
Humans
Male
Middle Aged
Registries*
Risk Factors
Takotsubo Cardiomyopathy / diagnosis*,  epidemiology,  etiology
Troponin T / blood
Chemical
Reg. No./Substance:
0/Troponin T; EC 2.7.3.2/Creatine Kinase

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