| [Clinical spectrum of tako-tsubo cardiomyopathy in Germany: results of the tako-tsubo registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK)]. | |
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MedLine Citation:
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PMID: 20859840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tako-tsubo cardiomyopathy (TTC) was first described in 1990 in Japan. A TTC registry was initiated by the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte (ALKK) in order to evaluate the clinical spectrum and the management of patients with this syndrome in Germany. METHODS: Patients from 37 hospitals were included in the registry if they fulfilled the following criteria: 1. acute chest symptoms or syncope, 2. new ischemic ECG changes with ST-segment elevation ± T-wave inversion, 3. reversible left ventricular regional wall motion abnormality not corresponding to a single coronary artery territory, 4. absence of significant coronary artery stenoses. RESULTS: 296 of the 324 patients (age 68 ± 12) were women (91 %) and 28 men (9 %). Leading symptoms were angina pectoris (72 %), dyspnoea (16 %), syncope (3 %) or resuscitation/cardiogenic shock (2 %). An antecedent trigger was found in 77 %. Time from symptom onset to hospital admission was 7,6 ± 6,9 hours. An acute coronary syndrome (ACS) was clinically suspected in 87 %. The ECG showed ST-segment elevation in 85 %. Cardiac troponin was elevated in more than 90 % of patients. Left ventricular ejection fraction by angiography was reduced to 49 ± 14 %. Initial medical treatment corresponded to the working diagnosis of an ACS. Catecholamines or an intraaortic balloon pump were necessary in 5 % and 1 %, respectively. Seven patients (2.2 %) died in hospital. CONCLUSION: TTC afflicts mainly women and presents clinically as an ACS in 87 %. Hospital mortality is low with symptomatic therapy. |
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Authors:
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B Schneider; A Athanasiadis; J Schwab; W Pistner; W von Scheidt; U Gottwald; R Schamberger; R Schoeller; A Bublak; W Toepel; K D Winter; U Sechtem |
Publication Detail:
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Type: English Abstract; Journal Article Date: 2010-09-21 |
Journal Detail:
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Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
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Languages: ger Pagination: 1908-13 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Klinik für Kardiologie, Sana Kliniken Lübeck GmbH, Lübeck. b.schneider@sana-luebeck.de |
Vernacular Title:
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Klinische Versorgung von Patienten mit Tako-Tsubo-Kardiomyopathie: Ergebnisse des Tako-Tsubo-Registers der ALKK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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diagnosis,
epidemiology,
etiology Adult Aged Aged, 80 and over Coronary Angiography Creatine Kinase / blood Cross-Sectional Studies Diagnosis, Differential Electrocardiography Female Germany Humans Male Middle Aged Registries* Risk Factors Takotsubo Cardiomyopathy / diagnosis*, epidemiology, etiology Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Troponin T; EC 2.7.3.2/Creatine Kinase |
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