Document Detail

Clinical significance of tissue Doppler imaging in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  17526987     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A transmitral E/septal Ea ratio > or =15 is a predictor of adverse outcome in cardiac disease, so it was hypothesized that a septal E/Ea >/=15 would predict the risk of adverse outcome, including sustained ventricular tachycardia (VT), cardiac arrest, implantable cardioverter defibrillator (ICD) discharge, or sudden death (SD) in patients with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS: The study group comprised 96 consecutive patients with HCM (median age 53 years) who completed all noninvasive tests for risk stratification. The endpoint of the study was defined as death, cardiac arrest, documented sustained VT, or ICD-discharge. The median follow-up was 20.6 months. All patients were alive at the end of follow-up, although 8 patients had reached the endpoint during the study period. The variables that were predictive of adverse clinical outcome were family history of premature SD (p=0.03), syncope (p<0.001), maximum wall thickness > or =3 cm (p=0.02), and septal E/Ea > or =15 (p<0.001). In a stepwise multivariable model the only independent prognostic indicator was a septal E/Ea > or =15 (relative risk 0.26, 95% confidence interval 0.2-0.58, p<0.001). The cumulative event-free survival rate was 78.9% in patients with septal E/Ea > or =15, and 100% in patients with septal E/Ea <15 (p=0.0003). CONCLUSIONS: Septal E/Ea > or =15 predicts patients with HCM who are at risk of sustained VT, cardiac arrest, ICD-discharge, or SD. (Circ J 2007; 71: 897 - 903).
Georgios K Efthimiadis; Georgios Giannakoulas; Despina G Parcharidou; Haralambos I Karvounis; Soterios T Mochlas; Ioannis H Styliadis; Christodoulos E Papadopoulos; Periklis Kounatiadis; Christodoulos I Pliakos; Georgios E Parcharidis; Georgios E Louridas
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  897-903     Citation Subset:  IM    
First Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Stilp. Kiriakidi 1, GR-54637 Thessaloniki, Greece.
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MeSH Terms
Cardiomyopathy, Hypertrophic / complications,  mortality,  physiopathology,  ultrasonography*
Death, Sudden, Cardiac* / etiology
Defibrillators, Implantable
Disease-Free Survival
Echocardiography, Doppler*
Follow-Up Studies
Heart Arrest / etiology,  mortality,  physiopathology,  ultrasonography*
Middle Aged
Risk Assessment
Risk Factors
Survival Rate
Tachycardia, Ventricular / etiology,  mortality,  physiopathology,  ultrasonography*

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