Document Detail

Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.
MedLine Citation:
PMID:  10762653     Owner:  NLM     Status:  MEDLINE    
Tenascin-C (TN-C) is one of extracellular matrix glycoproteins. We have immunohistochemically examined the TN-C expression of 33 primary osteosarcoma paraffin-embedded samples. The TN-C expression of the patient group with metastases was higher than that of the group without metastases at significant difference, and the survival curves show a tendency for poor outcome in the high grade staining group. Moreover, the supplemental TN-C had an effect of easier migration of a human osteosarcoma cell line (HOS) in vitro. The results may suggest that TN-C help osteosarcoma cells to migrate and to metastasize.
M Tanaka; T Yamazaki; N Araki; H Yoshikawa; T Yoshida; T Sakakura; A Uchida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of molecular medicine     Volume:  5     ISSN:  1107-3756     ISO Abbreviation:  Int. J. Mol. Med.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-25     Completed Date:  2000-05-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9810955     Medline TA:  Int J Mol Med     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  505-10     Citation Subset:  IM    
Department of Orthopaedic Surgery, Mie University faculty of Medicine, Tsu, Mie 514-8507, Japan.
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MeSH Terms
Bone Neoplasms / metabolism*,  pathology,  secondary*
Cell Division
Cell Movement
Child, Preschool
Osteosarcoma / metabolism*,  pathology,  secondary*
Predictive Value of Tests
Survival Rate
Tenascin / metabolism*
Tumor Cells, Cultured
Reg. No./Substance:

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