Document Detail


Clinical significance of soluble CD30 antigen in the sera of patients with untreated Hodgkin's disease.
MedLine Citation:
PMID:  1850308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The soluble form of the CD30 antigen (sCD30), an 88-kd glycoprotein that is released by Hodgkin's-derived cell lines in vitro, can be detected in patients with Hodgkin's lymphoma, adult (HTLV-1+) T-cell leukemia, rare cases of non-Hodgkin's lymphoma, and acute infectious mononucleosis (anti-EBV-IgM+). In a prospective study of 90 consecutive untreated patients with newly diagnosed Hodgkin's disease who were treated according to the protocols of the German Hodgkin Study group, 22% had detectable levels of sCD30 in their serum. sCD30 was only detected in patients with B symptoms (20 of 44 or 45%), and maximum sCD30 levels (88 U/mL) were found in stage IVB. Of 87 patients evaluable for response, sCD30+ patients had significantly lower rates of complete remission (9 of 20 or 45% v 60 of 67 or 90%; P less than .001) and higher rates of progressive disease (9 of 20 or 45% v 6 of 67 or 9%; P less than .001) than CD30+ patients. Similarly, freedom from treatment failure curves were significantly worse for CD30+ patients (P = .0003). sCD30 disappeared after successful treatment, but increased in patients with progressive disease. It was never detected in patients in complete remission or in healthy controls. We conclude that sCD30 is a valuable marker for disease activity and has prognostic significance in Hodgkin's disease.
Authors:
A Gause; C Pohl; A Tschiersch; L Da Costa; W Jung; V Diehl; D Hasenclever; M Pfreundschuh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood     Volume:  77     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-05-28     Completed Date:  1991-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1983-8     Citation Subset:  AIM; IM    
Affiliation:
Medizinische Klinik I, University of the Saarland, Homburg/Sarr, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD / blood
Antigens, CD30
Antigens, Differentiation / blood*
Antigens, Neoplasm / blood*
Hodgkin Disease / immunology*,  pathology,  therapy
Humans
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Prospective Studies
Remission Induction
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD30; 0/Antigens, Differentiation; 0/Antigens, Neoplasm; 0/Tumor Markers, Biological

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