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Clinical significance of serum zinc levels in cerebral ischemia.
MedLine Citation:
PMID:  21403822     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. Zinc mediates several vital physiological, enzymatic and cellular functions. The association between serum zinc and stroke outcome has not been previously evaluated. Methods. This single center retrospective study was conducted on consecutive stroke (n = 158) and TIA (n = 74) patients. We sought to determine whether serum zinc concentrations in patients with acute ischemic strokes were associated with stroke severity and poor functional status at discharge, respectively. Results. Overall, out of the 224 patients analyzed (mean age 67 years), 35.7% patients had low zinc levels (65 mcg/dL). Patients with stroke (n = 152) were more likely to have low zinc levels (OR = 2.62, CI 1.92-3.57, P < .003) compared to patients with TIA (n = 72). For patients with stroke (n = 152), multivariate analysis showed that low serum zinc levels (OR 2.82, CI 1.35-5.91, P = .035) and strokes with admission severe strokes (NIHSS > 8) (OR 2.68, CI 1.1-6.5, P = .03) were independently associated with poor functional status (MRS > 3) at discharge from the hospital. Conclusion. Low serum zinc concentrations are associated with more severe strokes on admission and poor functional status at discharge.
Authors:
Archit Bhatt; Muhammad U Farooq; Sailaja Enduri; Clement Pillainayagam; Bharath Naravetla; Anmar Razak; Adnan Safdar; Syed Hussain; Mounzer Kassab; Arshad Majid
Publication Detail:
Type:  Journal Article     Date:  2011-02-14
Journal Detail:
Title:  Stroke research and treatment     Volume:  2010     ISSN:  2042-0056     ISO Abbreviation:  Stroke Res Treat     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-14     Revised Date:  2011-07-26    
Medline Journal Info:
Nlm Unique ID:  101529024     Medline TA:  Stroke Res Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  245715     Citation Subset:  -    
Affiliation:
Division of Cerebrovascular Diseases and Sparrow Hospital William and Claire Dart Stroke Center, A-217 Clinical Center, Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48824, USA.
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