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Clinical significance of serum triple monoclonal components: A report of 6 cases and a review of the literature.
MedLine Citation:
PMID:  24315695     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6+43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation.
Authors:
Salvatore Guastafierro; Antonello Sica; Rita Rosaria Parascandola; Maria Giovanna Ferrara; Anna Di Martino; Luciano Pezone; Umberto Falcone
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-30
Journal Detail:
Title:  Leukemia research     Volume:  -     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-12-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Division of Hematology, Second University of Naples, Naples, Italy.
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