Document Detail

Clinical significance of serum albumin level in pregnancy-related hypertension.
MedLine Citation:
PMID:  21040199     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the usefulness of serum albumin level as a marker of severity in pregnancy-related hypertension.
METHODS: Of 454 patients with pregnancy-related hypertension who were admitted to Kyungpook National University Hospital between May 1999 and April 2008, the medical records and laboratory tests of 354 patients who met the inclusion criteria for the current study were reviewed. A comparison of the characteristics of each hypertension group and the correlation between serum albumin levels and the time to delivery, 24-h urine protein, and/or pregnancy outcomes were statistically analyzed using SPSS 12.0 (SPSS Korea, Korea).
RESULTS: Serum albumin level had a negative correlation with 24-h urine protein (Pearson's correlation coefficient = -0.481) and a positive correlation with time to delivery (= 0.389). Serum albumin ≤3.0 g/dL was highly associated with severe proteinuria (>2 g/day). There were significant differences in maternal or perinatal morbidity as a function of serum albumin level. If serum albumin level fell below 2.5 g/dL, the risks of ascites, hemolysis elevated liver enzyme low platelet (HELLP) syndrome and perinatal mortality significantly increased (odds ratio [OR] and 95% confidence interval [CI]: 3.5 [1.5-8.1], 12 [3.1-45], and 6.1 [1.7-22], respectively).
CONCLUSION: Serum albumin level in pregnancy-related hypertension is a significant determinant of disease severity and may be considered as a useful marker for predicting time to delivery, severe proteinuria, and pregnancy outcomes.
Won Joon Seong; Gun Oh Chong; Dae Gy Hong; Taek Hoo Lee; Yoon Soon Lee; Young Lae Cho; Sang Sik Chun; Il Soo Park
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Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-30     Completed Date:  2011-03-30     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1165-73     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, South Korea.
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MeSH Terms
Albumins / metabolism*
Biological Markers / blood
Hypertension, Pregnancy-Induced / blood*
Pregnancy Outcome
Severity of Illness Index
Reg. No./Substance:
0/Albumins; 0/Biological Markers

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