Document Detail

Clinical significance of pulmonary function tests. Pulmonary function after uncomplicated myocardial infarction.
MedLine Citation:
PMID:  891288     Owner:  NLM     Status:  MEDLINE    
Derangement of pulmonary function following myocardial infarction is related to the severity of hemodynamic dysfunction. Abnormalities of pulmonary function appear even in patients without clinical or radiologic evidence of congestive failure. There is a reduction in vital capacity and rates of air flow. There is evidence for dysfunction of "small airways" and diminished ventilation to dependent parts of the lung. Total lung capacity may be normal or reduced, and residual volume may be increased slightly in uncomplicated myocardial infarction. Residual volume falls with more pronounced pulmonary congestion and edema. Distribution of pulmonary perfusion is altered after myocardial infarction, with a shift of perfusion away from the dependent parts of the lung (bases) towards the apices. Pulmonary gas exchange is impaired, with hypoxemia (due to both ventilation-perfusion inequality and increased shunting); and the diffusing capacity for carbon monoxide is diminished. Dead space is increased. The basic pathophysiologic mechanism responsible for abnormalities of pulmonary function is increased pulmonary water, which may be very minimal with uncomplicated myocardial infarction and stay primarily in the pulmonary interstitial space, but becomes progressively more severe with eventual alveolar flooding and marked impairment of pulmonary function.
C A Hales; H Kazemi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  72     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-8     Citation Subset:  AIM; IM    
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MeSH Terms
Lung / radiography
Lung Volume Measurements
Myocardial Infarction / physiopathology*
Peak Expiratory Flow Rate
Pulmonary Edema / etiology
Respiratory Function Tests*
Ventilation-Perfusion Ratio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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