| Clinical significance of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy. | |
| | |
MedLine Citation:
|
PMID: 22088599 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the levels of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy at different stages. METHODS: A total of 80 patients with type 2 diabetes mellitus were enrolled in the present study. According to 24h urinary albumin excretion ratio and renal function, they were further divided into group of diabetes without microalbuminuria (DN0, n=20), microalbuminuria group (DN1, n=20), macroalbuminuria group (DN2, n=20) and renal insufficiency group (DN3, n=20). Another 20 healthy subjects were enrolled as control group (non-DM). Plasma CD146 and P-selectin were measured by ELISA. RESULTS: Plasma CD146 and P-selectin were significantly increased in patients with type 2 diabetes with microalbuminuria (DN1) compared with health control (CD146: 415.3±29.0 vs. 243.5±14.7ng/ml, P<0.05; P-selectin: 66.8±3.4 vs. 45.3±2.7ng/ml, P<0.001). With the development of diabetic nephropathy, both plasma CD146 and P-selectin level progressively rise, with the highest levels in patients with significant renal insufficiency (DN3: 515.9±36.9 and 81.5±5.1ng/ml respectively, P<0.001). Moreover, the increase in CD146 is positively co-related to the rise of P-selectin in patients with type 2 diabetes. CONCLUSION: Expression of CD146 and P-selectin in patients with type 2 diabetes is elevated, and they are positively correlated with severity of diabetic nephropathy. |
| | |
Authors:
|
Feng Wang; Tao Xing; Niansong Wang; Limei Liu |
Related Documents
:
|
17878449 - Effects of eggshell temperature and oxygen concentration on embryo growth and metabolis... 9737339 - Insulin receptor expression in primary and cultured osteoclast-like cells. 21496149 - Strict glucose control after acute stroke can be provided in the prehospital setting. 15499499 - Uptake and effects on detoxication enzymes of cypermethrin in embryos and tadpoles of a... 1439519 - Primary hyperparathyroidism or hypercalcaemia of malignancy? 17619219 - Immunolocalization of an acid phosphatase from pearl oyster (pinctada fucata) and its i... 1574959 - Maturation and insulin-like immunoreactivity in rat submandibular salivary glands: poss... 12086929 - Renal perfusion and the renal hemodynamic response to blocking the renin system in diab... 2180659 - Feasibility of adjustment of insulin dose by insulin-requiring type ii diabetic patients. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-14 |
Journal Detail:
|
Title: Cytokine Volume: - ISSN: 1096-0023 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9005353 Medline TA: Cytokine Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Nephrology and Rheumatology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective organ preservation in muscle-invasive bladder cancer: Review of the literature.
Next Document: The design and recombinant protein expression of a consensus porcine interferon: CoPoIFN-?