Document Detail

Clinical significance of perioperative immunonutrition for patients with esophageal cancer.
MedLine Citation:
PMID:  17876664     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We hypothesized that preoperative and/or postoperative enteral immune-enhanced formulas that are supplemented with arginine, omega-3 fatty acids, and RNA may reduce postoperative complications in patients undergoing esophagectomy for thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Forty patients who underwent esophagectomy were divided into three groups: group A (n = 20) received a control enteral diet (Erental) through the jejunostomy after surgery. group B (n = 6) received an enteral diet supplemented with immune-enhancing substrates (Impact) containing arginine, omega-3 fatty acids, and RNA after surgery. group C (n = 14) received the impact before and after surgery. RESULTS: Lymphocyte counts in group C on postoperative day (POD) 7 were somewhat higher than that in group A (p = 0.07) and significantly higher than in group B (p = 0.03). Furthermore the incidence of incisional wound infection in group C was significantly lower than that in group A (p = 0.03). Moreover, the duration of postoperative systemic inflammatory response syndrome (SIRS) was significantly shorter in group C than in group A (p < 0.05). CONCLUSIONS: This study reveals that the perioperative immune-enhanced formula may be superior to postoperative control enteral formulas in terms of reducing surgical wound infection and postoperative SIRS, which may result in serious postoperative complications for patients who have undergone esophagectomy.
Hiroya Takeuchi; Shunji Ikeuchi; Yoshiki Kawaguchi; Yuko Kitagawa; Yoh Isobe; Kiyoshi Kubochi; Masaki Kitajima; Sumio Matsumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  31     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-18     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2160-7     Citation Subset:  IM    
Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
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MeSH Terms
Arginine / administration & dosage
Carcinoma, Squamous Cell / immunology,  surgery
Enteral Nutrition
Esophageal Neoplasms / immunology,  surgery*
Esophagectomy* / adverse effects
Fatty Acids, Omega-3 / administration & dosage
Food, Formulated*
Lymphocyte Count
Middle Aged
Perioperative Care
Postoperative Complications / epidemiology
Surgical Wound Infection / prevention & control
Reg. No./Substance:
0/Fatty Acids, Omega-3; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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