Document Detail

Clinical significance of micrometastasis in lung and esophageal cancer: a new paradigm in thoracic oncology.
MedLine Citation:
PMID:  12118789     Owner:  NLM     Status:  MEDLINE    
In the past decade, detection of micrometastatic disease in different clinical samples including pleural lavage, lymph node, bone marrow, and blood has become a rapidly growing area of interest in research of non-small cell lung cancer and esophageal cancer. The results of these studies support the concept that, just as in many other solid malignancies, systemic spread may happen at an early stage in non-small cell lung cancer and esophageal cancer. Such systemic spread is often occult (micrometastases) at the time of primary diagnosis, which may have adverse effects on survival. Improved staging can be expected with information on micrometastases, and a subgroup of patients who will benefit most from adjuvant therapy might be identified. Although reliable and standard methods need to be developed before detection of micrometastasis is incorporated in the routine clinical practice, we suggest that it be considered an important correlate in clinical trials in non-small cell lung cancer and esophageal cancer.
Xiaolong Jiao; Mark J Krasna
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  74     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-16     Completed Date:  2002-08-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  AIM; IM    
Division of Thoracic Surgery, University of Maryland School of Medicine, Baltimore 21201, USA.
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MeSH Terms
Bone Marrow Neoplasms / pathology,  secondary*
Carcinoma, Non-Small-Cell Lung / secondary*
Esophageal Neoplasms / pathology*
Lung Neoplasms / pathology*
Lymph Nodes / pathology*
Lymphatic Metastasis
Neoplastic Cells, Circulating*
Pleural Neoplasms / pathology,  secondary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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