Document Detail


Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.
MedLine Citation:
PMID:  16911684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of the present paper was to determine the mechanism by which the level of coagulation factor XIIIA declines during the active phase of Crohn's disease. METHODS: The relationship between the activity of Crohn's disease and factor XIIIA was observed in 31 patients with Crohn's disease prospectively. The relationship between factor XIIIA and thrombin-antithrombin III complex (TAT), factor XIIIA expressed on the surface of peripheral monocytes, was also evaluated. RESULTS: During the first year, there were 11 patients with Crohn's disease in the active phase and 20 patients who remained in remission. The average of the lowest level of factor XIIIA among the patients in the active phase was 60.1%. The average of the lowest level of factor XIIIA in patients who remained in remission was 78.1% (P = 0.049). Among the 20 patients who remained in remission for 1 year, eight patients had factor XIIIA levels below 70%. Six of them required surgical enterectomies, on average 2 years and 1 month later. However, none of the 12 patients who remained in remission for 1 year and who never had factor XIIIA levels <70% had a surgical enterectomy during follow up of 4 years and 6 months (P = 0.002). The decline of factor XIIIA was not due to increased consumption secondary to blood coagulation (TAT), nor was it due to a decline in the function of monocytes that produce factor XIIIA. CONCLUSION: Factor XIIIA declines during the active phase of Crohn's disease because it might be consumed in the repair of injured tissue.
Authors:
Shingo Higaki; Kaori Nakano; Sachiko Onaka; Ayaka Amano; Yukari Tanioka; Katsunori Harada; Shinichi Hashimoto; Isao Sakaida; Kiwamu Okita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  21     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-16     Completed Date:  2007-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1407-11     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology and Hepatology, Yamaguch University School of Medicine, Ube, Yamaguchi, Japan. higaki@ms2.megaegg.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithrombin III
Crohn Disease / blood*,  pathology,  physiopathology,  therapy
Factor XIIIa / metabolism*
Female
Follow-Up Studies
Humans
Male
Monocytes / metabolism
Peptide Hydrolases / blood
Prospective Studies
Chemical
Reg. No./Substance:
0/antithrombin III-protease complex; 9000-94-6/Antithrombin III; EC 2.3.2.13/Factor XIIIa; EC 3.4.-/Peptide Hydrolases

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