Document Detail

Clinical significance of low levels of second-trimester maternal serum human chorionic gonadotropin.
MedLine Citation:
PMID:  7880431     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if unexplained low second-trimester maternal serum human chorionic gonadotropin (MShCG) is a useful predictor of complications of pregnancy. STUDY DESIGN: Between 2/1/90 and 1/3/91, 3,116 patients underwent prenatal screening using second-trimester maternal serum alpha-fetoprotein (MSAFP), MShCG and maternal serum unconjugated estriol (MSuE3). Among these, there were 160 patients with complete obstetrical history who had second-trimester MShCG < 0.4 multiples of the median (MoM). These were compared to 261 controls with complete obstetrical history and a normal second-trimester MSAFP, MSuE3 and MShCG. RESULTS: No differences were found in gestational age at delivery, neonatal weight, premature rupture of membranes or pregnancy loss. The relative risk of pregnancy-induced hypertension in the study group was 0.29 (p < 0.01) and that of gestational diabetes was 0.3 (p < 0.05). Only when low MShCG was associated with a high or low MSAFP or low MSuE3 was there a significantly increased loss of pregnancy (relative risk 11.7; p < 0.0001). CONCLUSION: The data suggest that second-trimester MShCG < 0.4 MoM by itself has no influence on the outcome of pregnancy.
J Santolaya-Forgas; L I Burd; B K Burton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  9     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-04-13     Completed Date:  1995-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  362-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Illinois at Chicago.
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MeSH Terms
Chorionic Gonadotropin / blood*
Diabetes, Gestational / blood
Fetal Death / blood
Hypertension / blood
Pregnancy Complications / blood
Pregnancy Outcome*
Pregnancy Trimester, Second
Risk Factors
Reg. No./Substance:
0/Chorionic Gonadotropin

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