| Clinical significance of low levels of second-trimester maternal serum human chorionic gonadotropin. | |
| | |
MedLine Citation:
|
PMID: 7880431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine if unexplained low second-trimester maternal serum human chorionic gonadotropin (MShCG) is a useful predictor of complications of pregnancy. STUDY DESIGN: Between 2/1/90 and 1/3/91, 3,116 patients underwent prenatal screening using second-trimester maternal serum alpha-fetoprotein (MSAFP), MShCG and maternal serum unconjugated estriol (MSuE3). Among these, there were 160 patients with complete obstetrical history who had second-trimester MShCG < 0.4 multiples of the median (MoM). These were compared to 261 controls with complete obstetrical history and a normal second-trimester MSAFP, MSuE3 and MShCG. RESULTS: No differences were found in gestational age at delivery, neonatal weight, premature rupture of membranes or pregnancy loss. The relative risk of pregnancy-induced hypertension in the study group was 0.29 (p < 0.01) and that of gestational diabetes was 0.3 (p < 0.05). Only when low MShCG was associated with a high or low MSAFP or low MSuE3 was there a significantly increased loss of pregnancy (relative risk 11.7; p < 0.0001). CONCLUSION: The data suggest that second-trimester MShCG < 0.4 MoM by itself has no influence on the outcome of pregnancy. |
| | |
Authors:
|
J Santolaya-Forgas; L I Burd; B K Burton |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Fetal diagnosis and therapy Volume: 9 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 1994 Nov-Dec |
Date Detail:
|
Created Date: 1995-04-13 Completed Date: 1995-04-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 362-6 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Illinois at Chicago. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chorionic Gonadotropin
/
blood* Diabetes, Gestational / blood Female Fetal Death / blood Humans Hypertension / blood Pregnancy Pregnancy Complications / blood Pregnancy Outcome* Pregnancy Trimester, Second Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Chorionic Gonadotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Screening of fetal stem cells for infection and cytogenetic abnormalities.
Next Document: Fluorescent in situ hybridization and second-trimester sonographic anomalies: uses and limitations.