Document Detail


Clinical significance of liver dysfunction in pregnancy-induced hypertension.
MedLine Citation:
PMID:  3348861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatic dysfunction is one of the frequent manifestations of multisystemic involvement in preeclampsia. This study was conducted to establish the impact of liver dysfunction on maternal and neonatal outcome in women with pregnancy-induced hypertension (PIH). The prevalence of liver dysfunction as determined by an elevated serum glutamic oxalacetic transaminase (SGOT) concentration was 21% in a population of 355 patients with PIH. Liver dysfunction was associated with the presence of severe hypertension, proteinuria, a lower platelet count, and renal compromise (elevated blood urea nitrogen, creatinine, and uric acid serum concentrations). Abdominal pain was also associated with an SGOT elevation. Liver dysfunction was associated with intrauterine growth retardation and prematurity. Furthermore, the association with these neonatal complications was independent from the severity of the hypertension and the presence of proteinuria. Thus, we conclude that liver dysfunction is a frequent complication of PIH and that it is an independent risk factor for maternal and perinatal complications.
Authors:
R Romero; J Vizoso; M Emamian; T Duffy; C Riely; T Halford; E Oyarzun; F Naftolin; J C Hobbins
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of perinatology     Volume:  5     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  146-51     Citation Subset:  IM    
Affiliation:
Yale University School of Medicine, Department of Obstetrics and Gynecology, New Haven, CT 06510.
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MeSH Terms
Descriptor/Qualifier:
Aspartate Aminotransferases / blood
Blood Pressure
Cesarean Section
Female
Humans
Hypertension / complications*,  physiopathology
Infant, Newborn
Infant, Newborn, Diseases / etiology
Liver Diseases / complications*,  enzymology
Models, Theoretical
Pregnancy
Pregnancy Complications, Cardiovascular*
Pregnancy Trimester, Third
Regression Analysis
Chemical
Reg. No./Substance:
EC 2.6.1.1/Aspartate Aminotransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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