Document Detail


Clinical significance of late potential in patients with Duchenne muscular dystrophy.
MedLine Citation:
PMID:  8255794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between late ventricular potentials (LP) and myocardial ischemic changes or ventricular arrhythmias was investigated in patients with Duchenne muscular dystrophy (DMD). Twenty-six DMD patients aged 10-33 years (mean 18.2 years) and 27 age-matched healthy volunteers were studied. Ventricular arrhythmias were detected by 24-h Holter ECGs and LPs were determined using signal-averaged ECGs. In DMD patients filtered QRS duration, late duration, and low-amplitude signal under 40 microV were significantly prolonged compared with those of the controls. The root mean square voltage of the f-QRS complex in the last 40 ms was lower in DMD patients than in the controls. None of the control subjects had LP. However, LP was detected in 8 (31%) of the 26 DMD patients. The patients with LP had more frequent ST-T depression and ventricular arrhythmias than the patients without LP. LP had 60% sensitivity and 87% specificity for documented ventricular arrhythmias. It is concluded that LP in DMD patients indicates the presence of substrate for ventricular arrhythmias associated with local myocardial fibrosis, and is useful in identifying those at high risk for malignant ventricular arrhythmias.
Authors:
M Kubo; S Matsuoka; Y Taguchi; H Akita; Y Kuroda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  14     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-13     Completed Date:  1994-01-13     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine, University of Tokushima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Arrhythmias, Cardiac / diagnosis,  epidemiology,  etiology*
Bundle-Branch Block / diagnosis,  etiology*
Electrocardiography / methods
Electrocardiography, Ambulatory
Heart Conduction System / physiopathology*
Humans
Male
Muscular Dystrophies / complications*,  physiopathology
Predictive Value of Tests
Risk Factors
Sensitivity and Specificity
Signal Processing, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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