| Clinical significance of intratumoral blood flow in cervical carcinoma assessed by color Doppler ultrasound. | |
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MedLine Citation:
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PMID: 7736396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Much evidence has suggested that vascular density reflects the clinical behavior of cancer. In this study, the intratumoral blood flow in cervical carcinomas was assessed by transvaginal color Doppler ultrasound, and its clinical significance was evaluated. METHODS: Sixty-five patients with Stage Ib-IIb cervical carcinoma exhibiting visible cervical tumor by transvaginal ultrasound were enrolled. All patients were scheduled for radical hysterectomy and pelvic lymph node dissection. Transvaginal color Doppler ultrasound was performed before surgery to search for blood flow signals from the tumor and the main uterine artery. The corresponding arterial resistance index (RI) was calculated. Clinical and pathologic data were recorded. A cytokinetic study was performed by propidium iodide staining and flow cytometry. The human papillomavirus (HPV) status was assessed by polymerase chain reaction. RESULTS: Intratumoral blood flow was detected by color Doppler ultrasound in 46.2% (30/65) of the tumors. Patients with detectable intratumoral blood flow exhibited significantly more pelvic lymph node metastasis (10/30 vs. 2/35, P = 0.005), a higher percentage of cancer cells in the S- + G2M-phase (30.02 +/- 18.54% vs. 19.35 +/- 11.21%, P < 0.005), and a higher prevalence of HPV infection (30/30 vs. 25/35, P = 0.001) when compared with those without intratumoral blood flow. No significant difference was observed concerning the patient's age, tumor size, clinical staging, histologic type, and DNA ploidy status between these two groups. Regression analysis of the intratumoral RI value on the S- + G2M-phase fraction showed linear regression (n = 30, r2 = 0.501, P < 0.01). The RI values of the main uterine artery showed no significant difference between these two groups. CONCLUSION: The intratumoral blood flow by transvaginal color Doppler ultrasound correlated well with a higher proliferation index, higher incidence of HPV infection, and pelvic lymph node metastasis in cervical carcinoma. |
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Authors:
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C Y Hsieh; C C Wu; T M Chen; C A Chen; C L Chen; J F Wang; C F Chang; F J Hsieh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 75 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-06-08 Completed Date: 1995-06-08 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2518-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, National Taiwan University, College of Medicine, Taipei. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteries Carcinoma / blood supply*, pathology, secondary, ultrasonography*, virology Cell Cycle DNA, Neoplasm / genetics Female Humans Linear Models Lymphatic Metastasis Middle Aged Neoplasm Staging Papillomaviridae / isolation & purification Papillomavirus Infections / pathology Ploidies Regional Blood Flow Tumor Virus Infections / pathology Ultrasonography, Doppler, Color* Uterine Cervical Neoplasms / blood supply*, pathology, ultrasonography*, virology Uterus / blood supply Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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