| Clinical significance of histopathologic patterns of cardiac amyloidosis. | |
MedLine Citation:
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PMID: 6748745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac amyloidosis may be asymptomatic or an important cause of progressive heart failure and refractory arrhythmia. To identify the morphologic markers of clinically significant cardiac amyloidosis, we analyzed the hearts of 47 patients with autopsy-proven cardiac amyloidosis (21 with primary amyloidosis [AL] and 26 with senile cardiac amyloidosis [SCA]) histologically for the extent and pattern of amyloid deposits. The extent of amyloid deposition was graded 1 through 4, corresponding with less than 10%, 10 to 25%, 26 to 50%, and more than 50% histologic involvement of the myocardium, respectively. The pattern of deposits was classified as nodular, perifiber, or mixed type, and the presence or absence of vascular involvement was determined. The hearts with primary amyloidosis showed predominantly high-grade deposits (76% grades 3 and 4), a perifiber (65%) or mixed (30%) pattern of deposits, and frequent (90%) vascular involvement. The hearts with senile cardiac amyloidosis tended to have low-grade deposits (62% grades 1 and 2), a nodular pattern (92%) of deposits, and infrequent (4%) vascular involvement. Clinically significant cardiac amyloidosis was associated with grade 2 or greater amyloid deposits in the heart and with involvement of intramyocardial arterioles. |
Authors:
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T J Smith; R A Kyle; J T Lie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mayo Clinic proceedings Volume: 59 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-09-10 Completed Date: 1984-09-10 Revised Date: 2013-12-13 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 547-55 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Amyloid / analysis Amyloidosis / metabolism, pathology* Cardiomyopathies / metabolism, pathology* Coronary Vessels / pathology Death, Sudden / etiology Female Heart Failure / etiology Humans Male Middle Aged Myocardium / analysis, ultrastructure Pericardium / analysis |
| Chemical | |
Reg. No./Substance:
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0/Amyloid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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