Document Detail

Clinical significance of focal topographic changes in the electroencephalogram (EEG) and evoked potentials (EP) of psychiatric patients.
MedLine Citation:
PMID:  1463657     Owner:  NLM     Status:  MEDLINE    
The relationship between psychiatric symptoms that respond to anticonvulsants and epileptic activity is still debated. Evidence linking electroencephalographic changes to treatment response is scarce and controversial, partly because of the poor scalp representation of limbic electrical activity. We studied the clinical relevance of focal topographic changes in the resting EEG, the visual evoked potential and the P300 response in 90 psychiatric patients, by evaluating response to anticonvulsants and development of neurological complications. The group with focal changes was compared to a group with epileptiform activity but no focal changes and a group with normal or diffusely altered EEG. Focal EEG and EP changes predicted good response to anticonvulsants, while the presence of epileptiform activity did not. Clinical seizures developed only in patients with focal changes and no anticonvulsants medication. Structural abnormalities and selective neuropsychological deficits were seen only in the focal group. There was an association of symptom type and the site of focus. We concluded that focal EEG and EP changes in psychiatric patients have important theoretical as well as practical implications.
M Gerez; A Tello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain topography     Volume:  5     ISSN:  0896-0267     ISO Abbreviation:  Brain Topogr     Publication Date:  1992  
Date Detail:
Created Date:  1993-01-21     Completed Date:  1993-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8903034     Medline TA:  Brain Topogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-10     Citation Subset:  IM    
Neurophysiology Department, Hospital Español de México, Mexico City.
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MeSH Terms
Analysis of Variance
Anticonvulsants / pharmacology
Brain / physiopathology*
Brain Mapping*
Electroencephalography* / drug effects
Evoked Potentials / drug effects,  physiology*
Mental Disorders / physiopathology*,  psychology
Psychiatric Status Rating Scales
Reg. No./Substance:

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